O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl thiophosphorofluoridate

Base Information

Chemical Name:O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl thiophosphorofluoridate
CAS No.:171081-38-2
Molecular Formula:C₃₅H₄₀FN₂O₈PS
Molecular Weight:698.749
Hs Code.:

Synonyms:O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl thiophosphorofluoridate

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Chemical Property of O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl thiophosphorofluoridate

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Technology Process of O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl thiophosphorofluoridate

There total 3 articles about O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl thiophosphorofluoridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 171081-30-4
O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl phosphorofluoridite

: 171081-38-2
O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl thiophosphorofluoridate

Guidance literature:: With (C₃H₇)2NH; sulfur; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1039/b103082p

Reference yield:

: C₃₇H₄₅FN₃O₇P

: 171081-38-2
O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl thiophosphorofluoridate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrazole / acetonitrile / 0.17 h / Ambient temperature

2: S

With 1H-tetrazole; sulfur; In acetonitrile;
DOI:10.1246/cl.1995.727

Reference yield:

: 76054-81-4
3'-O-(4,4'-dimethoxytrityl)thymidine

: 171081-38-2
O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl thiophosphorofluoridate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / TMSCl / tetrahydrofuran / 1 h / 20 °C

2: 97 percent / sulfur; (C₃H₇)2NH / tetrahydrofuran / 2 h / 20 °C

With chloro-trimethyl-silane; (C₃H₇)2NH; sulfur; In tetrahydrofuran;
DOI:10.1039/b103082p