4,6-Dichloro-7H-pyrrolo[2,3-D]pyrimidine

Base Information

Chemical Name:4,6-Dichloro-7H-pyrrolo[2,3-D]pyrimidine
CAS No.:97337-32-1
Molecular Formula:C6H3Cl2N3
Molecular Weight:188.016
Hs Code.:2933990090
European Community (EC) Number:817-223-1
DSSTox Substance ID:DTXSID60560175
Wikidata:Q72468124
Mol file:97337-32-1.mol

Synonyms:4,6-DICHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE;97337-32-1;MFCD11518912;SCHEMBL15618278;DTXSID60560175;CGTRULURZFVPIX-UHFFFAOYSA-N;AMY15668;AC8736;AKOS006325786;BS-49342;SY006873;7H-4,6-Dichloropyrrolo[2,3-d]pyrimidine;EN300-115313;4,6-bis(chloranyl)-7H-pyrrolo[2,3-d]pyrimidine;A845705;J-514134;Z1198329536

Suppliers and Price of 4,6-Dichloro-7H-pyrrolo[2,3-D]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4,?6-?Dichloro-?7H-?pyrrolo[2,?3-?d]?pyrimidine
250mg
$ 580.00

Crysdot
4,6-Dichloro-7H-pyrrolo[2,3-d]pyrimidine 95+%
1g
$ 882.00

Chemenu
4,6-Dichloro-7H-pyrrolo[2,3-d]pyrimidine 95%+
1g
$ 832.00

Biosynth Carbosynth
4,6-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
500 mg
$ 670.00

Biosynth Carbosynth
4,6-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
2 g
$ 1560.00

Biosynth Carbosynth
4,6-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
1 g
$ 850.00

Biosynth Carbosynth
4,6-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
100 mg
$ 230.00

Biosynth Carbosynth
4,6-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
250 mg
$ 435.00

Ambeed
4,6-Dichloro-7H-pyrrolo[2,3-d]pyrimidine 95%
250mg
$ 290.00

Ambeed
4,6-Dichloro-7H-pyrrolo[2,3-d]pyrimidine 95%
100mg
$ 125.00

Total 28 raw suppliers

Chemical Property of 4,6-Dichloro-7H-pyrrolo[2,3-D]pyrimidine

Chemical Property:

Refractive Index:1.723
PSA：41.57000
Density:1.675 g/cm³
LogP:2.26470
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:186.9704025
Heavy Atom Count:11
Complexity:155

Purity/Quality:

97% ^*data from raw suppliers

4,?6-?Dichloro-?7H-?pyrrolo[2,?3-?d]?pyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(NC2=C1C(=NC=N2)Cl)Cl
Uses 4,?6-?Dichloro-?7H-?pyrrolo[2,?3-?d]?pyrimidine is a reagent used in the preparation of nucleosides and tubercidin, as well as other antitumor compounds.

Technology Process of 4,6-Dichloro-7H-pyrrolo[2,3-D]pyrimidine

There total 6 articles about 4,6-Dichloro-7H-pyrrolo[2,3-D]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 4,6-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

: 97337-32-1
4,6-dichloropyrrolo<2,3-d>pyrimidine

Guidance literature:: With trifluoroacetic acid; at 20 ℃;
DOI:10.1002/ejoc.201501177

Reference yield: 47.0%

: 97337-31-0
pyrrolo<2,3-d>pyrimidine-4,6(3H,5H)-dione

: 97337-32-1
4,6-dichloropyrrolo<2,3-d>pyrimidine

Guidance literature:: With N,N-dimethyl-aniline; trichlorophosphate; for 3h; Heating;
DOI:10.1021/jm00148a015

Reference yield:

: 10359-15-6
diethyl 2-cyanosuccinate

: 97337-32-1
4,6-dichloropyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) HCl (gas), 2.) NaOEt / 1.) EtOH, 0-5 deg C, 24 h, 2.) EtOH, reflux, 2.5 h

2: 82 percent / NH₄OH, NaOH, Raney Ni / H₂O / 2 h / Heating

3: 47 percent / POCl₃, N,N-dimethylaniline / 3 h / Heating

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; sodium ethanolate; nickel; N,N-dimethyl-aniline; trichlorophosphate; In water;
DOI:10.1021/jm00148a015