1-benzyl-4-(R)-isobutyl-3-(R)-[4'-(S)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

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Chemical Name:1-benzyl-4-(R)-isobutyl-3-(R)-[4'-(S)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine
CAS No.:261896-44-0
Molecular Formula:C₂₅H₃₀N₂O₃
Molecular Weight:406.525
Hs Code.:

Synonyms:1-benzyl-4-(R)-isobutyl-3-(R)-[4'-(S)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

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Chemical Property of 1-benzyl-4-(R)-isobutyl-3-(R)-[4'-(S)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

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Technology Process of 1-benzyl-4-(R)-isobutyl-3-(R)-[4'-(S)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

There total 3 articles about 1-benzyl-4-(R)-isobutyl-3-(R)-[4'-(S)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 93102-05-7
N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

: 261896-43-9
3-[(E)-3-isobutylpropenoyl]-4-(S)-phenyl-2-oxazolidinone

: 261896-44-0
1-benzyl-4-(R)-isobutyl-3-(R)-[4'-(S)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

Guidance literature:: With trifluoroacetic acid; In toluene; at 0 - 22 ℃;
DOI:10.1016/S0040-4020(01)00549-X

Reference yield:

: 81530-29-2,148826-71-5
(E)-5-methylhex-2-enoic acid chloride

: 261896-44-0
1-benzyl-4-(R)-isobutyl-3-(R)-[4'-(S)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 22 °C

1.2: 6.25 g / tetrahydrofuran / 0 - 22 °C

2.1: 62 percent / TFA / toluene / 0 - 22 °C

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(01)00549-X

Reference yield:

: 41653-96-7,51424-01-2
(E)-5-methyl-2-hexenoic acid

: 261896-44-0
1-benzyl-4-(R)-isobutyl-3-(R)-[4'-(S)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride / toluene; dimethylformamide / 1 h / 22 °C

2.1: NaH / tetrahydrofuran / 1 h / 22 °C

2.2: 6.25 g / tetrahydrofuran / 0 - 22 °C

3.1: 62 percent / TFA / toluene / 0 - 22 °C

With oxalyl dichloride; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)00549-X