1-<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridyl>acetic acid

Base Information

• Chemical Name: 1-<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridyl>acetic acid
• CAS No.: 96661-34-6
• Molecular Formula: C₁₈H₂₀N₂O₃
• Molecular Weight: 312.368
• Mol file: 96661-34-6.mol

Synonyms:1-<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridyl>acetic acid

Chemical Property of 1-<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridyl>acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridyl>acetic acid

There total 2 articles about 1-<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridyl>acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromoacetic acid lithium salt (64916-53-6) + 3-(4',4'-dimethyl-4',5'-dihydro-oxazol-2'-yl)-N-lithio-4-phenyl-1,4-dihydropyridine → 1-<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridyl>acetic acid (96661-34-6)

Guidance literature:

In tetrahydrofuran; at 25 ℃; for 12h; Yield given;

Reference yield:

phenyllithium (591-51-5) → 1-<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridyl>acetic acid (96661-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / -78 °C

2: tetrahydrofuran / 12 h / 25 °C

In tetrahydrofuran;

Reference yield: 80.0%

1-<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridyl>acetic acid (96661-34-6) + p-bromophenacyl-6-β-<(aminophenylacetyl)amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate (51727-23-2) → p-bromophenacyl-6-β-<(4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylmethylcarbonylaminophenylacetyl)amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate (96661-42-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃; for 12h;

upstream raw materials:

bromoacetic acid lithium salt

phenyllithium

Downstream raw materials:

p-bromophenacyl-6-β-<(4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylmethylcarbonylaminophenylacetyl)amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt

6-β-<(4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylmethylcarbonylaminophenylacetyl)amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt