(E)-3-(4-Hydroxyphenyl)-2-thiophen-3-ylacrylic Acid Methyl Ester

Base Information

• Chemical Name: (E)-3-(4-Hydroxyphenyl)-2-thiophen-3-ylacrylic Acid Methyl Ester
• CAS No.: 376601-38-6
• Molecular Formula: C₁₄H₁₂O₃S
• Molecular Weight: 260.313
• Mol file: 376601-38-6.mol

Synonyms:(E)-3-(4-Hydroxyphenyl)-2-thiophen-3-ylacrylic Acid Methyl Ester

Chemical Property of (E)-3-(4-Hydroxyphenyl)-2-thiophen-3-ylacrylic Acid Methyl Ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (E)-3-(4-Hydroxyphenyl)-2-thiophen-3-ylacrylic Acid Methyl Ester

There total 2 articles about (E)-3-(4-Hydroxyphenyl)-2-thiophen-3-ylacrylic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.3%

→ (E)-3-(4-Hydroxyphenyl)-2-thiophen-3-ylacrylic Acid Methyl Ester (376601-38-6)

Guidance literature:

Reference yield:

3-thienyl iodide (10486-61-0) + methyl p-hydroxycinnamate (3943-97-3,19367-38-5,61240-27-5) → (E)-3-(4-Hydroxyphenyl)-2-thiophen-3-ylacrylic Acid Methyl Ester (376601-38-6) + C14H12O3S

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 36h; Overall yield = 55 percent; stereoselective reaction; Irradiation; Inert atmosphere;

DOI:10.1039/c9sc06184c

Reference yield:

2,4-dichloro-3-acetoxybenzyl alcohol + (E)-3-(4-Hydroxyphenyl)-2-thiophen-3-ylacrylic Acid Methyl Ester (376601-38-6) → (E)-3-[4-(3-acetoxy-2,6-dichlorobenzyloxy)phenyl]-2-thiophen-3-yl-acrylic acid methyl ester (376601-41-1)

Guidance literature:

With diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

upstream raw materials:

3-thienyl iodide

methyl p-hydroxycinnamate

Downstream raw materials:

(E)-3-[4-(3-acetoxy-2,6-dichlorobenzyloxy)phenyl]-2-thiophen-3-yl-acrylic acid methyl ester