(20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate

Base Information

Chemical Name:(20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate
CAS No.:849791-82-8
Molecular Formula:C₃₁H₄₅NO₆
Molecular Weight:527.701
Hs Code.:

Synonyms:(20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate

Suppliers and Price of (20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate

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Technology Process of (20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate

There total 5 articles about (20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 3970-21-6
2-Methoxyethoxymethyl chloride

: 849791-81-7
(20R)-3α-hydroxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate

: 849791-82-8
(20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.tet.2005.01.055

Reference yield:

: 251984-45-9
(20R)-7-Norpregn-5-ene-3β,20-diyl 3-acetate 20-benzoate

: 849791-82-8
(20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / perchloric acid; N-bromo acetamide / dioxane / 1 h / 15 °C

2: 97 percent / potassium carbonate / methanol; H₂O / 20 h / 20 °C

3: 64 percent / BF₃*Et₂O / tetrahydrofuran; diethyl ether / 20 h / 20 °C

4: 52 percent / potassium hydrogen carbonate; hydroxylamine hydrochloride / methanol / 5 h / Heating

5: 97 percent / pyridine / 4 h / 0 °C

6: 26 percent / potassium nitrite / dimethylsulfoxide / 115 °C

7: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 18 h / 20 °C

With pyridine; perchloric acid; potassium nitrite; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; potassium carbonate; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; N-bromoacetamide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; 5: Beckmann rearrangement;
DOI:10.1016/j.tet.2005.01.055

Reference yield:

: 849791-76-0
(20R)-5,6β-epoxy-3β-hydroxy-7-nor-5β-pregnan-20-yl benzoate

: 849791-82-8
(20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / BF₃*Et₂O / tetrahydrofuran; diethyl ether / 20 h / 20 °C

2: 52 percent / potassium hydrogen carbonate; hydroxylamine hydrochloride / methanol / 5 h / Heating

3: 97 percent / pyridine / 4 h / 0 °C

4: 26 percent / potassium nitrite / dimethylsulfoxide / 115 °C

5: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 18 h / 20 °C

With pyridine; potassium nitrite; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; 3: Beckmann rearrangement;
DOI:10.1016/j.tet.2005.01.055