ethyl 7-(2,6-difluorobenzyl)-4,7-dihydro-3-methyl-2-(4-nitrophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate

Base Information

Chemical Name:ethyl 7-(2,6-difluorobenzyl)-4,7-dihydro-3-methyl-2-(4-nitrophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate
CAS No.:174069-42-2
Molecular Formula:C₂₄H₁₈F₂N₂O₅S
Molecular Weight:484.48
Hs Code.:

Synonyms:ethyl 7-(2,6-difluorobenzyl)-4,7-dihydro-3-methyl-2-(4-nitrophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate

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Chemical Property of ethyl 7-(2,6-difluorobenzyl)-4,7-dihydro-3-methyl-2-(4-nitrophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate

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Technology Process of ethyl 7-(2,6-difluorobenzyl)-4,7-dihydro-3-methyl-2-(4-nitrophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate

There total 8 articles about ethyl 7-(2,6-difluorobenzyl)-4,7-dihydro-3-methyl-2-(4-nitrophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 174069-44-4
ethyl 7-(2,6-difluorobenzyl)-4,7-dihydro-3-methyl-4-oxo-2-phenylthieno[2,3-b]pyridine-5-carboxylate

: 174069-42-2
ethyl 7-(2,6-difluorobenzyl)-4,7-dihydro-3-methyl-2-(4-nitrophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate

Guidance literature:: With sodium nitrate; sulfuric acid; at 0 ℃;
DOI:10.1021/jm9803673

Reference yield:

: 697-73-4
2,6-difluorobenzyl chloride

: 174069-42-2
ethyl 7-(2,6-difluorobenzyl)-4,7-dihydro-3-methyl-2-(4-nitrophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃; KI / dimethylformamide / 20 - 50 °C

2: 71 percent / NaNO₃; H₂SO₄ / 0 °C

With sodium nitrate; sulfuric acid; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm0512894

Reference yield:

: 4815-38-7
ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate

: 174069-42-2
ethyl 7-(2,6-difluorobenzyl)-4,7-dihydro-3-methyl-2-(4-nitrophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 120 °C

2: KOH / ethanol; dioxane / 70 °C

3: 60 percent / polyphosphate ester / 120 °C

4: 90 percent / K₂CO₃; KI / dimethylformamide / 20 - 50 °C

5: 71 percent / NaNO₃; H₂SO₄ / 0 °C

With potassium hydroxide; sodium nitrate; polyphosphate ester; sulfuric acid; potassium carbonate; potassium iodide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0512894