(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{(S)-3-methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-butyryloxy}-propionylamino)-pent-2-enoic acid ethyl ester

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Chemical Name:(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{(S)-3-methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-butyryloxy}-propionylamino)-pent-2-enoic acid ethyl ester
CAS No.:249736-19-4
Molecular Formula:C₃₉H₄₇FN₄O₁₀
Molecular Weight:750.821
Hs Code.:

(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{(S)-3-methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-butyryloxy}-propionylamino)-pent-2-enoic acid ethyl ester

Synonyms:(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{(S)-3-methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-butyryloxy}-propionylamino)-pent-2-enoic acid ethyl ester

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Chemical Property of (E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{(S)-3-methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-butyryloxy}-propionylamino)-pent-2-enoic acid ethyl ester

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Technology Process of (E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{(S)-3-methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-butyryloxy}-propionylamino)-pent-2-enoic acid ethyl ester

There total 9 articles about (E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{(S)-3-methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-butyryloxy}-propionylamino)-pent-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: (E)-(S)-4-Amino-5-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-pent-2-enoic acid ethyl ester

: 394217-83-5
(S)-3-Methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-butyric acid (S)-1-carboxy-2-(4-fluoro-phenyl)-ethyl ester

: 249736-19-4
(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{(S)-3-methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-butyryloxy}-propionylamino)-pent-2-enoic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00542-X

Reference yield:

: 39499-34-8
5-methyl-3-isoxazolyl chloride

: 249736-19-4
(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{(S)-3-methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-butyryloxy}-propionylamino)-pent-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / pyr. / CH₂Cl₂

2: 95 percent / Pd(PPh₃)4; morpholine / tetrahydrofuran

3: 72 percent / HATU; iPr₂NEt / dimethylformamide

With morpholine; pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00542-X

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 249736-19-4
(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{(S)-3-methyl-2-[(5-methyl-isoxazole-3-carbonyl)-amino]-butyryloxy}-propionylamino)-pent-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / DCC; DMAP / CH₂Cl₂

2: 99 percent / HCl; aq. K₂CO₃ / dioxane

3: 82 percent / pyr. / CH₂Cl₂

4: 95 percent / Pd(PPh₃)4; morpholine / tetrahydrofuran

5: 72 percent / HATU; iPr₂NEt / dimethylformamide

With morpholine; pyridine; hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00542-X