methyl 4-(3-benzyl-6-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)-5-bromo-2-methoxybenzoate

Base Information

Chemical Name:methyl 4-(3-benzyl-6-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)-5-bromo-2-methoxybenzoate
CAS No.:1352448-44-2
Molecular Formula:C₂₁H₂₃BrN₂O₄
Molecular Weight:447.329
Hs Code.:

Synonyms:methyl 4-(3-benzyl-6-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)-5-bromo-2-methoxybenzoate

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Chemical Property of methyl 4-(3-benzyl-6-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)-5-bromo-2-methoxybenzoate

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Technology Process of methyl 4-(3-benzyl-6-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)-5-bromo-2-methoxybenzoate

There total 2 articles about methyl 4-(3-benzyl-6-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)-5-bromo-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1352448-60-2
methyl 4-(3-benzyl-6-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoate

: 1352448-44-2
methyl 4-(3-benzyl-6-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)-5-bromo-2-methoxybenzoate

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 - 60 ℃;
DOI:10.1021/ol2031763

Reference yield:

: 1352448-28-2
1-benzyl-4-methyltetrahydropyrimidin-2(1H)-one

: 1352448-44-2
methyl 4-(3-benzyl-6-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)-5-bromo-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C / Inert atmosphere

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 - 60 °C

With N-Bromosuccinimide; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide; 1: Buchwald-Hartwig N-arylation;
DOI:10.1021/ol2031763

Reference yield: 61.0%

: 1352448-44-2
methyl 4-(3-benzyl-6-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)-5-bromo-2-methoxybenzoate

: 1352448-82-8
methyl 2-benzyl-8-methoxy-1-oxo-1,2,3,4,4a,5-hexahydropyrimido[1,6-a]indole-7-carboxylate

Guidance literature:: With palladium⁽⁰⁾bis(tricyclohexylphosphine); sodium carbonate; potassium carbonate; Trimethylacetic acid; In toluene; at 140 ℃; for 48h;
DOI:10.1021/ol2031763