(R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester

Base Information

• Chemical Name: (R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester
• CAS No.: 890528-64-0
• Molecular Formula: C₄₃H₆₀O₆Si
• Molecular Weight: 701.031

Synonyms:(R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester

Chemical Property of (R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester

There total 1 articles about (R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 3α-hydroxy-7α-acetoxy-12-oxocholanate (71837-87-1) + tert-butylchlorodiphenylsilane (58479-61-1) → (R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester (890528-64-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2006.03.072

Reference yield:

(R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester (890528-64-0) → (R)-4-[(3R,5R,7R,8R,9S,10S,13R,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester (890528-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dioxane / Photolysis

2.1: BF₃*OEt₂ / benzene / 25 °C

3.1: DBU; CS₂; CH₃I / dimethylformamide / 0 - 20 °C

3.2: 86 percent / Bu₃SnH; AIBN / toluene / 120 °C

With carbon disulfide; boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; methyl iodide; In 1,4-dioxane; N,N-dimethyl-formamide; benzene; 3.1: Barton deoxygenation;

DOI:10.1016/j.tetlet.2006.03.072

Reference yield:

(R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester (890528-64-0) → (3R,9R,10R,13R,15R,17R)-3-(tert-Butyl-diphenyl-silanyloxy)-17-((1S,2S,3S,4R)-2,3-dihydroxy-1,4,5-trimethyl-hexyl)-10,13-dimethyl-2,3,9,10,11,12,13,15,16,17-decahydro-1H-20-oxa-cyclopropa[14,15]cyclopenta[a]phenanthren-6-one

Guidance literature:

Multi-step reaction with 18 steps

1.1: dioxane / Photolysis

2.1: BF₃*OEt₂ / benzene / 25 °C

3.1: DBU; CS₂; CH₃I / dimethylformamide / 0 - 20 °C

3.2: 86 percent / Bu₃SnH; AIBN / toluene / 120 °C

4.1: LDA; PhSeBr / tetrahydrofuran / 4 h / -78 °C

4.2: 86 percent / aq. H₂O₂ / methanol / 2 h / 20 °C

5.1: OsO₄; K₃Fe(CN)6 / H₂O; 2-methyl-propan-2-ol / 20 h / 20 °C

6.1: 96 percent / PTSA / CH₂Cl₂ / 0 - 20 °C

7.1: 84 percent / aq. NaOH / methanol / 1 h / 0 °C

8.1: 95 percent / NaH / dimethylformamide / 0 - 20 °C

9.1: 36 h / -78 - 0 °C

10.1: Dess-Martin agent; aq. NaHCO₃ / CH₂Cl₂ / 2 h / 20 °C

11.1: 82 percent / TiCl; Zn / CH₂Cl₂ / 25 °C

12.1: NH₂OH / ethyl acetate / 20 °C

13.1: 98 percent / CAN / acetonitrile; H₂O / 0.5 h / 0 °C

14.1: DIAD; HCO₂H; Ph₃P

14.2: 92 percent / NaBH₄ / methanol

15.1: 87 percent / t-BuOOH; Ti(iPrO)4 / H₂O; 2-methyl-propan-2-ol / 20 h / 20 °C

16.1: SOCl₂; pyridine / tetrahydrofuran / 0 - 20 °C

16.2: 57 percent / SeO₂ / acetonitrile / 36 h / 20 °C

17.1: 83 percent / IBX / dimethylsulfoxide / 20 h / 85 °C

18.1: 95 percent / AcCl / methanol / 6 h / 0 °C

With pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; carbon disulfide; sodium hydroxide; osmium(VIII) oxide; formic acid; thionyl chloride; ammonium cerium(IV) nitrate; thallium chloride; di-isopropyl azodicarboxylate; Phenylselenyl bromide; boron trifluoride diethyl etherate; hydroxylamine; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetyl chloride; triphenylphosphine; potassium hexacyanoferrate(III); zinc; lithium diisopropyl amide; methyl iodide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; benzene; 3.1: Barton deoxygenation / 14.1: Mitsunobu reaction / 15.1: Sharpless epoxidation;

DOI:10.1016/j.tetlet.2006.03.072

upstream raw materials:

methyl 3α-hydroxy-7α-acetoxy-12-oxocholanate

tert-butylchlorodiphenylsilane

Downstream raw materials:

(E)-(R)-4-[(3R,5R,7R,8R,9S,10S,13R,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-pent-2-enoic acid methyl ester

(R)-4-[(3R,5R,7R,8R,9S,10S,13R,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester

(R)-4-[(3R,5R,7R,8R,9S,10S,13R,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-12-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester

5-{1-[3-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethyl}-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 890528-64-0 (R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-Acetoxy-3-(tert-butyl-diphenyl-silanyloxy)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send