Technology Process of N-(2-(2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)ethyl)-N-methyl-2-nitrobenzenesulfonamide
There total 5 articles about N-(2-(2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)ethyl)-N-methyl-2-nitrobenzenesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
water; toluene;
at 130 ℃;
Sealed vessel;
Inert atmosphere;
Microwave irradiation;
DOI:10.1016/j.bmc.2012.05.005
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h
1.2: 14 h / 0 - 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene / 130 °C / Sealed vessel; Inert atmosphere; Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); sodium hydride; sodium carbonate;
In
water; N,N-dimethyl-formamide; toluene; mineral oil;
2.1: Suzuki coupling;
DOI:10.1016/j.bmc.2012.05.005
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h
2.2: 14 h / 0 - 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene / 130 °C / Sealed vessel; Inert atmosphere; Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); sodium hydride; sodium carbonate; triethylamine;
In
dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;
3.1: Suzuki coupling;
DOI:10.1016/j.bmc.2012.05.005
