1-(4-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-phenyl)-2,2,2-trifluoro-ethanol

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Chemical Name:1-(4-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-phenyl)-2,2,2-trifluoro-ethanol
CAS No.:1426082-24-7
Molecular Formula:C₂₆H₂₅F₃N₄O₂
Molecular Weight:482.505
Hs Code.:

Synonyms:1-(4-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-phenyl)-2,2,2-trifluoro-ethanol

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Chemical Property of 1-(4-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-phenyl)-2,2,2-trifluoro-ethanol

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Technology Process of 1-(4-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-phenyl)-2,2,2-trifluoro-ethanol

There total 4 articles about 1-(4-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-phenyl)-2,2,2-trifluoro-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1251931-23-3
{2-[4-(4-bromo-5-pyridin-4-yl-1H-imidazol-2-yl)-phenoxy]-ethyl}-dimethyl-amine

: 1426082-73-6
2,2,2-trifluoro-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethanol

: 1426082-24-7
1-(4-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-phenyl)-2,2,2-trifluoro-ethanol

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 110 ℃; for 2h;
DOI:10.1016/j.bmc.2012.12.035

Reference yield:

: 1251931-22-2
{2-[4-(4-bromo-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-2-yl)-phenoxy]-ethyl}-dimethyl-amine

: 1426082-24-7
1-(4-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-phenyl)-2,2,2-trifluoro-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / 60 °C

2: potassium carbonate; triphenylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / 110 °C

With hydrogenchloride; water; palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; 2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.12.035

Reference yield:

: 16184-89-7
4'-bromo-2,2,2-trifluoroacetophenone

: 1426082-24-7
1-(4-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-phenyl)-2,2,2-trifluoro-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; sodium tetrahydroborate / methanol / 1.5 h / 20 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 90 °C

3: potassium carbonate; triphenylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; potassium acetate; palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 3: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.12.035