1-(1,3-dioxan-2-yl)-3,3-dimethyl-4-nitro-5-(3-p-tolylpyrrol-2-yl)-1-pentanone

Base Information

Chemical Name:1-(1,3-dioxan-2-yl)-3,3-dimethyl-4-nitro-5-(3-p-tolylpyrrol-2-yl)-1-pentanone
CAS No.:1345981-16-9
Molecular Formula:C₂₂H₂₈N₂O₅
Molecular Weight:400.475
Hs Code.:

Synonyms:1-(1,3-dioxan-2-yl)-3,3-dimethyl-4-nitro-5-(3-p-tolylpyrrol-2-yl)-1-pentanone

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Chemical Property of 1-(1,3-dioxan-2-yl)-3,3-dimethyl-4-nitro-5-(3-p-tolylpyrrol-2-yl)-1-pentanone

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Technology Process of 1-(1,3-dioxan-2-yl)-3,3-dimethyl-4-nitro-5-(3-p-tolylpyrrol-2-yl)-1-pentanone

There total 2 articles about 1-(1,3-dioxan-2-yl)-3,3-dimethyl-4-nitro-5-(3-p-tolylpyrrol-2-yl)-1-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 859513-64-7
3-(4-methylphenyl)-2-(2-nitroethyl)pyrrole

: 1345981-11-4
1-(1,3-dioxan-2-yl)-3-methyl-2-buten-1-one

: 1345981-16-9
1-(1,3-dioxan-2-yl)-3,3-dimethyl-4-nitro-5-(3-p-tolylpyrrol-2-yl)-1-pentanone

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 20 ℃;
DOI:10.1021/jo201967k

Reference yield:

: 1345981-09-0
1,1-diethoxy-4-methyl-3-penten-2-one

: 1345981-16-9
1-(1,3-dioxan-2-yl)-3,3-dimethyl-4-nitro-5-(3-p-tolylpyrrol-2-yl)-1-pentanone

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / benzene / 4.5 h / 80 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C

With toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzene;
DOI:10.1021/jo201967k

Reference yield: 18.0%

: 1345981-16-9
1-(1,3-dioxan-2-yl)-3,3-dimethyl-4-nitro-5-(3-p-tolylpyrrol-2-yl)-1-pentanone

: 1345981-22-7
1-(1,3-dioxolane-2-yl)-2,3-dihydro-3,3-dimethyl-7-p-tolyldipyrrin

Guidance literature:: 1-(1,3-dioxan-2-yl)-3,3-dimethyl-4-nitro-5-(3-p-tolylpyrrol-2-yl)-1-pentanone; With sodium methylate; In tetrahydrofuran; methanol; at 0 ℃; for 0.666667h; Inert atmosphere;

With hydrogenchloride; titanium(III) chloride; ammonium acetate; In tetrahydrofuran; methanol; water; at 20 ℃; Inert atmosphere;
DOI:10.1021/jo201967k