(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]butanoate

Base Information

Chemical Name:(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]butanoate
CAS No.:1330630-33-5
Molecular Formula:C₃₅H₄₅NO₂
Molecular Weight:511.748
Hs Code.:

Synonyms:(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]butanoate

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Chemical Property of (1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]butanoate

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Technology Process of (1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]butanoate

There total 10 articles about (1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 81002-19-9
(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (E)-but-2-enoate

: (1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (αR,3S)-3-[N-benzyl-N-(α-methylbenzyl)amino]butanoate

: 1330630-33-5
(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]butanoate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.5h; Inert atmosphere;

(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (E)-but-2-enoate; In tetrahydrofuran; hexanes; at -78 ℃; for 2h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.102

Reference yield:

: C₁₉H₂₂ClNO

: 65253-04-5
(-)-8-phenylmenthol

: 1330630-33-5
(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]butanoate

Guidance literature:: C₁₉H₂₂ClNO; (-)-8-phenylmenthol; In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; Saturated solution;
DOI:10.1016/j.tet.2011.05.102

Reference yield:

: 205057-17-6
(5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexanone

: 1330630-33-5
(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 3 h / Reflux

2.1: sodium; isopropyl alcohol / toluene / 8 h / Reflux; Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 0 - 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 18 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C / Inert atmosphere

5.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; sodium; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran; hexanes; ethanol; water; toluene;
DOI:10.1016/j.tet.2011.05.102