methyl (1S,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Base Information

Chemical Name:methyl (1S,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
CAS No.:274677-70-2
Molecular Formula:C₂₂H₂₄N₂O₅
Molecular Weight:396.443
Hs Code.:

Synonyms:methyl (1S,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

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Chemical Property of methyl (1S,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

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Technology Process of methyl (1S,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

There total 6 articles about methyl (1S,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 274677-50-8
(S)-3-(1H-Indol-3-yl)-2-{[1-(3,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-propionic acid methyl ester

: 274677-71-3
methyl (1R,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

: 274677-70-2
methyl (1S,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/jm9905662

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 274677-71-3
methyl (1R,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

: 274677-70-2
methyl (1S,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: With trifluoroacetic acid; In water; at 20 ℃; for 12h; Overall yield = 100 percent; Overall yield = 0.98 g;
DOI:10.1016/j.ejmech.2019.111919

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 4299-70-1
L-tryptophan methyl ester

: 274677-71-3
methyl (1R,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

: 274677-70-2
methyl (1S,3S)-1-(3,4,5-trimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 18h; optical yield given as %de; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2008.05.022