tert-butyl 6-O-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate

Base Information

Chemical Name:tert-butyl 6-O-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate
CAS No.:756869-51-9
Molecular Formula:C₄₁H₅₀N₂O₈S
Molecular Weight:730.923
Hs Code.:

tert-butyl 6-O-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate

Synonyms:tert-butyl 6-O-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate

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Chemical Property of tert-butyl 6-O-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate

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Technology Process of tert-butyl 6-O-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate

There total 8 articles about tert-butyl 6-O-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 756869-51-9
tert-butyl 6-O-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / K₂CO₃ / dimethylformamide / 12 h / 100 °C

2: AcOH / 1,2-dichloro-ethane / 4 h / 20 °C

3: Na(OAc)3BH / 1,2-dichloro-ethane / 12 h

4: 94 percent / i-Pr₂NEt / dimethylformamide / 12 h / 90 °C

5: 95 percent / Pd(PPh₃)4; PhSiH₃ / CH₂Cl₂ / 1 h / 20 °C

6: 62 percent / K₂CO₃; 18-crown-6 / dimethylsulfoxide / 18 h / 80 °C

7: Fe; aq. NH₄Cl / ethanol / 1 h / 80 °C

8: pyridine / 1 h / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether; phenylsilane; sodium tris(acetoxy)borohydride; iron; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.021

Reference yield:

: 135054-68-1
(3R,5S)-6-<(methylsulfonyl)oxy>-3,5-O-isopropylidene-3,5-dihydroxyhexanoic acid tert-butyl ester

: 756869-51-9
tert-butyl 6-O-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / K₂CO₃; 18-crown-6 / dimethylsulfoxide / 18 h / 80 °C

2: Fe; aq. NH₄Cl / ethanol / 1 h / 80 °C

3: pyridine / 1 h / 20 °C

With pyridine; 18-crown-6 ether; iron; potassium carbonate; ammonium chloride; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2004.06.021

Reference yield:

: 123-31-9,8027-02-9
hydroquinone

: 756869-51-9
tert-butyl 6-O-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate

Guidance literature:: Multi-step reaction with 9 steps

1: 41 percent / K₂CO₃ / acetone / 12 h / 40 °C

2: 81 percent / K₂CO₃ / dimethylformamide / 12 h / 100 °C

3: AcOH / 1,2-dichloro-ethane / 4 h / 20 °C

4: Na(OAc)3BH / 1,2-dichloro-ethane / 12 h

5: 94 percent / i-Pr₂NEt / dimethylformamide / 12 h / 90 °C

6: 95 percent / Pd(PPh₃)4; PhSiH₃ / CH₂Cl₂ / 1 h / 20 °C

7: 62 percent / K₂CO₃; 18-crown-6 / dimethylsulfoxide / 18 h / 80 °C

8: Fe; aq. NH₄Cl / ethanol / 1 h / 80 °C

9: pyridine / 1 h / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether; phenylsilane; sodium tris(acetoxy)borohydride; iron; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2004.06.021