N¹-<<3-<3-(guanidinoacetamido)benzene-1-carboxamido>benzen-1-yl>carbonyl>-N⁴,N⁸-bis(tert-butoxycarbonyl)spermidine hydrochloride

Base Information

• Chemical Name: N¹-<<3-<3-(guanidinoacetamido)benzene-1-carboxamido>benzen-1-yl>carbonyl>-N⁴,N⁸-bis(tert-butoxycarbonyl)spermidine hydrochloride
• CAS No.: 133765-75-0
• Molecular Formula: C₃₄H₅₀N₈O₇*ClH
• Molecular Weight: 719.281

Synonyms:N¹-<<3-<3-(guanidinoacetamido)benzene-1-carboxamido>benzen-1-yl>carbonyl>-N⁴,N⁸-bis(tert-butoxycarbonyl)spermidine hydrochloride

Chemical Property of N¹-<<3-<3-(guanidinoacetamido)benzene-1-carboxamido>benzen-1-yl>carbonyl>-N⁴,N⁸-bis(tert-butoxycarbonyl)spermidine hydrochloride

Chemical Property:

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Technology Process of N¹-<<3-<3-(guanidinoacetamido)benzene-1-carboxamido>benzen-1-yl>carbonyl>-N⁴,N⁸-bis(tert-butoxycarbonyl)spermidine hydrochloride

There total 6 articles about N¹-<<3-<3-(guanidinoacetamido)benzene-1-carboxamido>benzen-1-yl>carbonyl>-N⁴,N⁸-bis(tert-butoxycarbonyl)spermidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

guanidineacetic acid hydrochloride (14901-20-3) + N1-<<3-(3-aminobenzene-1-carboxamido)benzen-1-yl>carbonyl>-N4,N8-bis(tert-butoxycarbonyl)spermidine (133765-73-8) → N1-<<3-<3-(guanidinoacetamido)benzene-1-carboxamido>benzen-1-yl>carbonyl>-N4,N8-bis(tert-butoxycarbonyl)spermidine hydrochloride (133765-75-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/0223-5234(91)90058-U

Reference yield:

N1,N5-di-boc-spermidine (68076-39-1) → N1-<<3-<3-(guanidinoacetamido)benzene-1-carboxamido>benzen-1-yl>carbonyl>-N4,N8-bis(tert-butoxycarbonyl)spermidine hydrochloride (133765-75-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 55 percent / pyridine / acetonitrile / 3 h / Ambient temperature

2: 96 percent / H₂ / 10percent Pd/C / methanol / 4 h / 760 Torr / Ambient temperature

3: 92 percent / pyridine / acetonitrile / 1 h / Ambient temperature

4: 95 percent / H₂ / 10percent Pd/C / methanol / 4 h / 760 Torr / Ambient temperature

5: 53 percent / dicyclohexylcarbodiimide (DCC) / dimethylformamide / Ambient temperature

With pyridine; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/0223-5234(91)90058-U

Reference yield:

N1-<(3-aminobenzen-1-yl)carbonyl>-N4,N8-bis(tert-butoxycarbonyl)spermidine (133765-71-6) → N1-<<3-<3-(guanidinoacetamido)benzene-1-carboxamido>benzen-1-yl>carbonyl>-N4,N8-bis(tert-butoxycarbonyl)spermidine hydrochloride (133765-75-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / pyridine / acetonitrile / 1 h / Ambient temperature

2: 95 percent / H₂ / 10percent Pd/C / methanol / 4 h / 760 Torr / Ambient temperature

3: 53 percent / dicyclohexylcarbodiimide (DCC) / dimethylformamide / Ambient temperature

With pyridine; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/0223-5234(91)90058-U

upstream raw materials:

guanidineacetic acid hydrochloride

N¹-<<3-(3-aminobenzene-1-carboxamido)benzen-1-yl>carbonyl>-N⁴,N⁸-bis(tert-butoxycarbonyl)spermidine

N₁,N₅-di-boc-spermidine

N¹-<(3-aminobenzen-1-yl)carbonyl>-N⁴,N⁸-bis(tert-butoxycarbonyl)spermidine

Downstream raw materials:

N¹-<<3-<3-(guanidinoacetamido)benzene-1-carboxamido>benzen-1-yl>carbonyl>spermidine tris(trifluoroacetate)

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