3-(methylamino)-2,6-dinitrobenzonitrile

Base Information

• Chemical Name: 3-(methylamino)-2,6-dinitrobenzonitrile
• CAS No.: 103884-25-9
• Molecular Formula: C₈H₆N₄O₄
• Molecular Weight: 222.16
• Mol file: 103884-25-9.mol

Synonyms:3-(methylamino)-2,6-dinitrobenzonitrile

Chemical Property of 3-(methylamino)-2,6-dinitrobenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(methylamino)-2,6-dinitrobenzonitrile

There total 1 articles about 3-(methylamino)-2,6-dinitrobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

N-methyl-2,4-dinitroaniline (2044-88-4) + potassium cyanide (151-50-8) → 3-(methylamino)-2,6-dinitrobenzonitrile (103884-25-9)

Guidance literature:

With potassium hexacyanoferrate(III); In methanol; water; at 55 ℃; for 6h;

DOI:10.1021/jo00371a029

Reference yield:

3-(methylamino)-2,6-dinitrobenzonitrile (103884-25-9) → 5-<(N-benzoyl(thiocarbamoyl))amino>-1-methylbenzimidadole-4-carbonitrile (103884-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) H₂ / 1.) 10percent Pd/C / 1.) EtOH, 52 psi, reflux, 2 h, 2.) reflux, 2 h

2: 98.6 percent / H₂O / 24 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In water;

DOI:10.1021/jo00371a029

Reference yield:

3-(methylamino)-2,6-dinitrobenzonitrile (103884-25-9) → 5-<(N-benzoyl-S-methyl(isothiocarbamoyl))amino>-1-methylbenzimidazole-4-carbonitrile (103884-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) H₂ / 1.) 10percent Pd/C / 1.) EtOH, 52 psi, reflux, 2 h, 2.) reflux, 2 h

2: 98.6 percent / H₂O / 24 h / Ambient temperature

3: NaOH / H₂O / 24 h

With sodium hydroxide; hydrogen; palladium on activated charcoal; In water;

DOI:10.1021/jo00371a029

upstream raw materials:

N-methyl-2,4-dinitroaniline

potassium cyanide

Downstream raw materials:

5-amino-1-methylbenzimidazole-4-carbonitrile

5-(N-benzoylguanidino)-1-methylbenzimidazole-4-carbonitrile

5-<(N-benzoyl(thiocarbamoyl))amino>-1-methylbenzimidadole-4-carbonitrile

5-<(N-benzoyl-S-methyl(isothiocarbamoyl))amino>-1-methylbenzimidazole-4-carbonitrile

Refernces