1-(3-cyanophenyl)-5-[[5-(2'-t-butylaminosulfonylphenyl)pyrimidin-2-yl]-aminocarbonyl]-3-trifluoromethyl-pyrazole

Base Information

Chemical Name:1-(3-cyanophenyl)-5-[[5-(2'-t-butylaminosulfonylphenyl)pyrimidin-2-yl]-aminocarbonyl]-3-trifluoromethyl-pyrazole
CAS No.:209959-15-9
Molecular Formula:C₂₆H₂₂F₃N₇O₃S
Molecular Weight:569.567
Hs Code.:

Synonyms:1-(3-cyanophenyl)-5-[[5-(2'-t-butylaminosulfonylphenyl)pyrimidin-2-yl]-aminocarbonyl]-3-trifluoromethyl-pyrazole

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Chemical Property of 1-(3-cyanophenyl)-5-[[5-(2'-t-butylaminosulfonylphenyl)pyrimidin-2-yl]-aminocarbonyl]-3-trifluoromethyl-pyrazole

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Technology Process of 1-(3-cyanophenyl)-5-[[5-(2'-t-butylaminosulfonylphenyl)pyrimidin-2-yl]-aminocarbonyl]-3-trifluoromethyl-pyrazole

There total 6 articles about 1-(3-cyanophenyl)-5-[[5-(2'-t-butylaminosulfonylphenyl)pyrimidin-2-yl]-aminocarbonyl]-3-trifluoromethyl-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 218302-19-3
2-(6-amino-3-pyrimidinyl)benzene-tert-butylsulfonamide

: N-(3-cyanophenyl)-3-trifluoromethyl-pyrazole-5-carboxylic acid chloride

: 209959-15-9
1-(3-cyanophenyl)-5-[[5-(2'-t-butylaminosulfonylphenyl)pyrimidin-2-yl]-aminocarbonyl]-3-trifluoromethyl-pyrazole

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;
DOI:10.1021/jm000409z

Reference yield:

: 367-57-7
1,1,1-Trifluoro-2,4-pentanedione

: 209959-15-9
1-(3-cyanophenyl)-5-[[5-(2'-t-butylaminosulfonylphenyl)pyrimidin-2-yl]-aminocarbonyl]-3-trifluoromethyl-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: 89.9 percent / aq. NaIO₄; RuCl₃*H₂O / acetonitrile / 18 h / 20 °C

2: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 20 °C

3: N,N-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With dmap; ruthenium trichloride; sodium periodate; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;
DOI:10.1021/jm000409z

Reference yield:

: 27246-81-7
3-bromophenylhydrazine hydrochloride

: 209959-15-9
1-(3-cyanophenyl)-5-[[5-(2'-t-butylaminosulfonylphenyl)pyrimidin-2-yl]-aminocarbonyl]-3-trifluoromethyl-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: 89.9 percent / aq. NaIO₄; RuCl₃*H₂O / acetonitrile / 18 h / 20 °C

2: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 20 °C

3: N,N-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With dmap; ruthenium trichloride; sodium periodate; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;
DOI:10.1021/jm000409z