methyl <3-<4-(4,5-diphenyl-2-oxazolyl)-2-methyl-5-oxazolyl>phenoxy>acetate

Base Information

Chemical Name:methyl <3-<4-(4,5-diphenyl-2-oxazolyl)-2-methyl-5-oxazolyl>phenoxy>acetate
CAS No.:152575-88-7
Molecular Formula:C₂₈H₂₂N₂O₅
Molecular Weight:466.493
Hs Code.:

Synonyms:methyl <3-<4-(4,5-diphenyl-2-oxazolyl)-2-methyl-5-oxazolyl>phenoxy>acetate

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Chemical Property of methyl <3-<4-(4,5-diphenyl-2-oxazolyl)-2-methyl-5-oxazolyl>phenoxy>acetate

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Technology Process of methyl <3-<4-(4,5-diphenyl-2-oxazolyl)-2-methyl-5-oxazolyl>phenoxy>acetate

There total 7 articles about methyl <3-<4-(4,5-diphenyl-2-oxazolyl)-2-methyl-5-oxazolyl>phenoxy>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 96-32-2
bromoacetic acid methyl ester

: 152575-87-6
3-<4-(4,5-diphenyl-2-oxazolyl)-2-methyl-5-oxazolyl>phenol

: 152575-88-7
methyl <3-<4-(4,5-diphenyl-2-oxazolyl)-2-methyl-5-oxazolyl>phenoxy>acetate

Guidance literature:: With potassium carbonate; In acetonitrile; Heating;
DOI:10.1021/jm00076a018

Reference yield:

: 84758-91-8
benzyl [(4,5-diphenyl-2-oxazolyl)-methyl]carbamate

: 152575-88-7
methyl <3-<4-(4,5-diphenyl-2-oxazolyl)-2-methyl-5-oxazolyl>phenoxy>acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 5percent aq. HCO₂H / 10percent Pd/C / 18 h / Ambient temperature

2: toluene / 2.5 h / 70 °C

3: 98 percent / POCl₃, Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 67 percent / DPPA, DBN / dimethylformamide

5: 1.) s-BuLi, DMPU / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 30 min

6: 83 percent / BBr₃ / CH₂Cl₂ / 18 h / Ambient temperature

7: 42 percent / K₂CO₃ / acetonitrile / Heating

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; formic acid; 2,6-dichloro-benzonitrile; diphenyl-phosphinic acid; sec.-butyllithium; boron tribromide; potassium carbonate; triethylamine; trichlorophosphate; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm00076a018

Reference yield:

: 33162-00-4
2-Aminomethyl-4,5-diphenyl-1,3-oxazole

: 152575-88-7
methyl <3-<4-(4,5-diphenyl-2-oxazolyl)-2-methyl-5-oxazolyl>phenoxy>acetate

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 2.5 h / 70 °C

2: 98 percent / POCl₃, Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: 67 percent / DPPA, DBN / dimethylformamide

4: 1.) s-BuLi, DMPU / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 30 min

5: 83 percent / BBr₃ / CH₂Cl₂ / 18 h / Ambient temperature

6: 42 percent / K₂CO₃ / acetonitrile / Heating

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 2,6-dichloro-benzonitrile; diphenyl-phosphinic acid; sec.-butyllithium; boron tribromide; potassium carbonate; triethylamine; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm00076a018