tert-butyl 1'-[3-chloro-4-(dimethylcarbamoyl)phenyl]-[4,4'-bipiperidine]-1-carboxylate

Base Information

Chemical Name:tert-butyl 1'-[3-chloro-4-(dimethylcarbamoyl)phenyl]-[4,4'-bipiperidine]-1-carboxylate
CAS No.:1034825-09-6
Molecular Formula:C₂₄H₃₆ClN₃O₃
Molecular Weight:450.021
Hs Code.:

Synonyms:tert-butyl 1'-[3-chloro-4-(dimethylcarbamoyl)phenyl]-[4,4'-bipiperidine]-1-carboxylate

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Chemical Property of tert-butyl 1'-[3-chloro-4-(dimethylcarbamoyl)phenyl]-[4,4'-bipiperidine]-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 1'-[3-chloro-4-(dimethylcarbamoyl)phenyl]-[4,4'-bipiperidine]-1-carboxylate

There total 4 articles about tert-butyl 1'-[3-chloro-4-(dimethylcarbamoyl)phenyl]-[4,4'-bipiperidine]-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 893420-19-4
4-bromo-2-chloro-N,N-dimethylbenzamide

: 171049-35-7
1-tert-butoxycarbonyl-4,4'-bipiperidine

: 1034825-09-6
tert-butyl 1'-[3-chloro-4-(dimethylcarbamoyl)phenyl]-[4,4'-bipiperidine]-1-carboxylate

Guidance literature:: With palladium diacetate; sodium t-butanolate; DavePhos; In toluene; at 80 ℃; for 5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00176

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1034825-09-6
tert-butyl 1'-[3-chloro-4-(dimethylcarbamoyl)phenyl]-[4,4'-bipiperidine]-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; ethanol / 20 °C / pH Ca_. 8 - Ca_. 9

2: sodium t-butanolate; DavePhos; palladium diacetate / toluene / 5 h / 80 °C / Inert atmosphere

With palladium diacetate; sodium hydroxide; sodium t-butanolate; DavePhos; In ethanol; water; toluene;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 78619-84-8
4,4'-bipiperidine dihydrochloride

: 1034825-09-6
tert-butyl 1'-[3-chloro-4-(dimethylcarbamoyl)phenyl]-[4,4'-bipiperidine]-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 12 h / 20 °C / pH 8 - 9

2: palladium diacetate; DavePhos; sodium t-butanolate / toluene / 5 h / 80 °C / Inert atmosphere

With palladium diacetate; sodium hydroxide; sodium t-butanolate; DavePhos; In ethanol; water; toluene;
DOI:10.1021/acs.jmedchem.6b00176