4-(2,2-diphenyl-1-ethyl)-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isothiazole

Base Information

Chemical Name:4-(2,2-diphenyl-1-ethyl)-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isothiazole
CAS No.:879491-14-2
Molecular Formula:C₂₇H₃₂N₂O₃S
Molecular Weight:464.629
Hs Code.:

Synonyms:4-(2,2-diphenyl-1-ethyl)-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isothiazole

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Chemical Property of 4-(2,2-diphenyl-1-ethyl)-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isothiazole

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Technology Process of 4-(2,2-diphenyl-1-ethyl)-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isothiazole

There total 9 articles about 4-(2,2-diphenyl-1-ethyl)-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 879491-07-3
4-(2,2-diphenyl-1-hydroxyethyl)-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isothiazole

: 879491-14-2
4-(2,2-diphenyl-1-ethyl)-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isothiazole

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 50 ℃; for 2h;
DOI:10.1021/jm050987l

Reference yield:

: 879490-98-9
(E)-3-(1-methoxycarbonyl-4-piperidyl)-2-propenamide

: 879491-14-2
4-(2,2-diphenyl-1-ethyl)-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isothiazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: 77 percent / 72 h / 20 °C

2.1: aq. NaOH / 4 h / 20 °C

3.1: aq. H₂O₂ / 24 h / 45 °C

3.2: 1.41 g / SO₂Cl₂ / 1,2-dichloro-ethane / 48 h / 20 °C

4.1: K₂CO₃ / dimethylformamide / 0.5 h / 60 °C

4.2: 56 percent / dimethylformamide / 20 h / 60 °C

5.1: 82 percent / ICl; aq. AcOH / 18 h / 80 °C

6.1: EtMgBr / tetrahydrofuran / 3 h / 0 °C

6.2: 45 percent / tetrahydrofuran / 20 °C

7.1: 78 percent / Et₃SiH; TFA / CH₂Cl₂ / 2 h / 50 °C

With triethylsilane; sodium hydroxide; ethylmagnesium bromide; dihydrogen peroxide; Iodine monochloride; potassium carbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050987l

Reference yield:

: 879491-00-6
3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isothiazole

: 879491-14-2
4-(2,2-diphenyl-1-ethyl)-3-isopropoxy-5-(1-methoxycarbonyl-4-piperidyl)isothiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 82 percent / ICl; aq. AcOH / 18 h / 80 °C

2.1: EtMgBr / tetrahydrofuran / 3 h / 0 °C

2.2: 45 percent / tetrahydrofuran / 20 °C

3.1: 78 percent / Et₃SiH; TFA / CH₂Cl₂ / 2 h / 50 °C

With triethylsilane; ethylmagnesium bromide; Iodine monochloride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050987l