ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Base Information

• Chemical Name: ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate
• CAS No.: 133719-55-8
• Molecular Formula: C₁₈H₂₂N₆O₂
• Molecular Weight: 354.412

Synonyms:ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Chemical Property of ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

There total 6 articles about ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate (165900-66-3) → ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate (133719-54-7) + ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate (133719-55-8)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 ℃; for 6h;

DOI:10.1248/cpb.43.256

Reference yield:

ethyl 4-(methylamino)benzoate (10541-82-9) → ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate (133719-55-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 80 percent / K₂CO₃, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 13 h / 80 °C

2: 99 percent / H₂, acetic acid / Raney Ni / ethanol; tetrahydrofuran / 0.5 h

3: 1.) LDA, 2.) I₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 20 min

4: 1.) NaH, DMSO / 1.) 0 deg C, 5 min, 2.) DMSO, RT, 1.5 h

5: 74 percent / EtONa / ethanol; tetrahydrofuran / 3 h / Heating

6: 32 percent / BH₃*THF / tetrahydrofuran / 6 h / 0 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; borane-THF; hydrogen; iodine; sodium ethanolate; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; lithium diisopropyl amide; nickel; In tetrahydrofuran; ethanol;

DOI:10.1248/cpb.43.256

Reference yield:

methyl 4-crotonate (165900-79-8) → ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate (133719-55-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 99 percent / H₂, acetic acid / Raney Ni / ethanol; tetrahydrofuran / 0.5 h

2: 1.) LDA, 2.) I₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 20 min

3: 1.) NaH, DMSO / 1.) 0 deg C, 5 min, 2.) DMSO, RT, 1.5 h

4: 74 percent / EtONa / ethanol; tetrahydrofuran / 3 h / Heating

5: 32 percent / BH₃*THF / tetrahydrofuran / 6 h / 0 °C

With borane-THF; hydrogen; iodine; sodium ethanolate; sodium hydride; acetic acid; dimethyl sulfoxide; lithium diisopropyl amide; nickel; In tetrahydrofuran; ethanol;

DOI:10.1248/cpb.43.256

upstream raw materials:

ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

ethyl 4-(methylamino)benzoate

methyl 4-crotonate

methyl 4-butyrate

Downstream raw materials:

4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoic acid

diethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoyl-L-glutamate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 133719-55-8 ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send