(2S)-2-({[2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)biphenyl-4-yl]carbonyl}amino)-4-methylpentanoic acid

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Chemical Name:(2S)-2-({[2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)biphenyl-4-yl]carbonyl}amino)-4-methylpentanoic acid
CAS No.:917113-87-2
Molecular Formula:C₃₂H₃₅N₃O₇
Molecular Weight:573.646
Hs Code.:

Synonyms:(2S)-2-({[2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)biphenyl-4-yl]carbonyl}amino)-4-methylpentanoic acid

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Chemical Property of (2S)-2-({[2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)biphenyl-4-yl]carbonyl}amino)-4-methylpentanoic acid

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Technology Process of (2S)-2-({[2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)biphenyl-4-yl]carbonyl}amino)-4-methylpentanoic acid

There total 9 articles about (2S)-2-({[2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)biphenyl-4-yl]carbonyl}amino)-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917114-03-5
4-(1-benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2'-(3-carbamoyl-phenylcarbamoyl)-biphenyl-2-carboxylic acid tert-butyl ester

: 917113-87-2
(2S)-2-({[2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)biphenyl-4-yl]carbonyl}amino)-4-methylpentanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 576170-38-2
3-(tert-butyl) 1-methyl 4-hydroxyisophthalate

: 917113-87-2
(2S)-2-({[2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)biphenyl-4-yl]carbonyl}amino)-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 13.3 g / pyridine / CH₂Cl₂ / 0.5 h / 20 °C

2: 4.19 g / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 3 h / 100 °C

3: 3.75 g / sodium chlorite; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O; acetonitrile / 12 h / 20 °C

4: 2.29 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 60 °C

5: 1.87 g / NaOH / ethanol; H₂O / 12 h / 20 °C

6: 0.200 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 12 h / 20 °C

7: 0.154 g / H₂ / Pd/C / methanol / 4 h / 20 °C

With pyridine; sodium hydroxide; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071

Reference yield:

: 790230-23-8
3-tert-butyl 1-methyl 4-{[(trifluoromethyl)sulfonyl]oxy}isophthalate

: 917113-87-2
(2S)-2-({[2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-2-(tert-butoxycarbonyl)biphenyl-4-yl]carbonyl}amino)-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 4.19 g / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 3 h / 100 °C

2: 3.75 g / sodium chlorite; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O; acetonitrile / 12 h / 20 °C

3: 2.29 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 60 °C

4: 1.87 g / NaOH / ethanol; H₂O / 12 h / 20 °C

5: 0.200 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 12 h / 20 °C

6: 0.154 g / H₂ / Pd/C / methanol / 4 h / 20 °C

With sodium hydroxide; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.071