5-N-(trans-4-aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

Base Information

Chemical Name:5-N-(trans-4-aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine
CAS No.:761452-56-6
Molecular Formula:C₁₈H₂₀ClFN₆
Molecular Weight:374.848
Hs Code.:

Synonyms:5-N-(trans-4-aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

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Chemical Property of 5-N-(trans-4-aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

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Technology Process of 5-N-(trans-4-aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

There total 4 articles about 5-N-(trans-4-aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₈ClFN₆O₂

: 761452-56-6
5-N-(trans-4-aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm300411k

Reference yield:

: 1393882-19-3
5-chloro-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine

: 761452-56-6
5-N-(trans-4-aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / 1,4-dioxane / 6 h / 20 - 60 °C

2: acetonitrile / 18 h / 80 - 85 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With dmap; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm300411k

Reference yield:

: 57489-77-7
5,7-dichloropyrazolo[1,5-a]pyrimidine

: 761452-56-6
5-N-(trans-4-aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / isopropyl alcohol / 15 h / 80 °C

2: dmap / 1,4-dioxane / 6 h / 20 - 60 °C

3: acetonitrile / 18 h / 80 - 85 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With dmap; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm300411k