N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]-4-ethoxy-benzamide

Base Information

Chemical Name:N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]-4-ethoxy-benzamide
CAS No.:1310816-20-6
Molecular Formula:C₂₅H₂₆N₄O₃
Molecular Weight:430.506
Hs Code.:

Synonyms:N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]-4-ethoxy-benzamide

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Chemical Property of N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]-4-ethoxy-benzamide

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Technology Process of N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]-4-ethoxy-benzamide

There total 21 articles about N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]-4-ethoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1310816-91-1
1-[(4-ethoxybenzoyl)amino]cyclopropanecarboxylic acid

: (4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-amine dihydroiodide

: 1310816-20-6
N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]-4-ethoxy-benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16.1667h; Cooling with ice;

Reference yield: 80.0%

: 1310816-97-7
(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-amine

: 1310816-91-1
1-[(4-ethoxybenzoyl)amino]cyclopropanecarboxylic acid

: 1310816-20-6
N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]-4-ethoxy-benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 145485-03-6
((R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)carbamic acid tert-butyl ester

: 1310816-20-6
N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]-4-ethoxy-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; water / methanol / 1 h

2.1: sodium carbonate / water; acetonitrile / 4 h / 20 °C

3.1: Lawessons reagent / toluene / 2.5 h / 100 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / dichloromethane / 49 h / 20 °C / Industry scale

5.1: formic acid / 1.33 h / 95 °C / Industry scale

5.2: pH 7

5.3: Chiralpak AD (20 micron) column

6.1: trimethylsilyl iodide / dichloromethane / 16 h / 20 °C / Cooling with ice

6.2: 0.17 h / 20 °C / Cooling with ice

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 16.17 h / 20 °C / Cooling with ice

With Lawessons reagent; hydrogenchloride; formic acid; trimethylsilyl iodide; water; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid; In methanol; dichloromethane; water; toluene; acetonitrile;