((5S)-4-methyl-4-azaspiro[2.4]heptane-5-yl)methyl methanesulfonate

Base Information

• Chemical Name: ((5S)-4-methyl-4-azaspiro[2.4]heptane-5-yl)methyl methanesulfonate
• CAS No.: 1221443-18-0
• Molecular Formula: C₉H₁₇NO₃S
• Molecular Weight: 219.305
• Mol file: 1221443-18-0.mol

Synonyms:((5S)-4-methyl-4-azaspiro[2.4]heptane-5-yl)methyl methanesulfonate

Chemical Property of ((5S)-4-methyl-4-azaspiro[2.4]heptane-5-yl)methyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((5S)-4-methyl-4-azaspiro[2.4]heptane-5-yl)methyl methanesulfonate

There total 1 articles about ((5S)-4-methyl-4-azaspiro[2.4]heptane-5-yl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-Pyroglutaminol (17342-08-4) → ((5S)-4-methyl-4-azaspiro[2.4]heptane-5-yl)methyl methanesulfonate (1221443-18-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 4 h / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -40 °C / Inert atmosphere

2.2: -40 °C / Inert atmosphere

3.1: titanium(IV) isopropylate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: methanol; toluene-4-sulfonic acid / 50 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.2: 4 h / 0 °C / Inert atmosphere

With titanium(IV) isopropylate; methanol; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield: 6.0%

((5S)-4-methyl-4-azaspiro[2.4]heptane-5-yl)methyl methanesulfonate (1221443-18-0) + N-(3-fluoro-4-(7-hydroxyquinolin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (1221443-46-4) → N-(4-(7-(((5S)-4-methyl-4-azaspiro[2.4]heptane-5-yl)methoxy)quinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide (1221442-35-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl acetamide; at 40 ℃; for 72h; Inert atmosphere;

upstream raw materials:

(S)-Pyroglutaminol

Downstream raw materials:

N-(4-(7-(((5S)-4-methyl-4-azaspiro[2.4]heptane-5-yl)methoxy)quinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide