di-tert-butyl {4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl}-L-glutamate

Base Information

• Chemical Name: di-tert-butyl {4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl}-L-glutamate
• CAS No.: 298211-09-3
• Molecular Formula: C₂₄H₃₄Cl₂F₂N₂O₅
• Molecular Weight: 539.447
• Mol file: 298211-09-3.mol

Synonyms:di-tert-butyl {4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl}-L-glutamate

Chemical Property of di-tert-butyl {4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl}-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl {4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl}-L-glutamate

There total 5 articles about di-tert-butyl {4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{4-[bis-(2-methanesulfonyloxy-ethyl)-amino]-3,5-difluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester (298211-19-5) → di-tert-butyl {4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl}-L-glutamate (298211-09-3)

Guidance literature:

With lithium chloride; In N,N-dimethyl acetamide; at 90 ℃; for 1h;

DOI:10.1021/jm0502182

Reference yield:

2-{4-[bis-(2-hydroxy-ethyl)-amino]-3,5-difluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester (298211-18-4) → di-tert-butyl {4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl}-L-glutamate (298211-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N; DMAP / CH₂Cl₂ / 16 h / cooling

2: 0.55 g / LiCl / N,N-dimethyl-acetamide / 1 h / 90 °C

With dmap; triethylamine; lithium chloride; In dichloromethane; N,N-dimethyl acetamide;

DOI:10.1021/jm0502182

Reference yield:

3,4,5-trifluorobenzonitrile (134227-45-5) → di-tert-butyl {4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl}-L-glutamate (298211-09-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 50 °C

2: 87 percent / aq. NaOH / ethanol

3: triethylamine; diethylcyanophosphonate / dimethylformamide / 72 h

4: Et₃N; DMAP / CH₂Cl₂ / 16 h / cooling

5: 0.55 g / LiCl / N,N-dimethyl-acetamide / 1 h / 90 °C

With dmap; sodium hydroxide; diethyl cyanophosphonate; triethylamine; lithium chloride; In ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

DOI:10.1021/jm0502182

upstream raw materials:

2-{4-[bis-(2-methanesulfonyloxy-ethyl)-amino]-3,5-difluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester

2-{4-[bis-(2-hydroxy-ethyl)-amino]-3,5-difluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester

3,4,5-trifluorobenzonitrile

4-(bis(2-hydroxyethyl)amino)-3,5-difluorobenzonitrile