3-[4-(3-(4-chloro)phenyl-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl]-2-propenoic acid

Base Information

Chemical Name:3-[4-(3-(4-chloro)phenyl-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl]-2-propenoic acid
CAS No.:615252-68-1
Molecular Formula:C₁₇H₁₄ClNO₃
Molecular Weight:315.756
Hs Code.:

Synonyms:3-[4-(3-(4-chloro)phenyl-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl]-2-propenoic acid

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Chemical Property of 3-[4-(3-(4-chloro)phenyl-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl]-2-propenoic acid

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Technology Process of 3-[4-(3-(4-chloro)phenyl-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl]-2-propenoic acid

There total 3 articles about 3-[4-(3-(4-chloro)phenyl-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl]-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 99-91-2
para-chloroacetophenone

: 615252-64-7
ethyl 3-(4-formyl-1-methyl-1H-pyrrol-2-yl)-2-propenoate

: 615252-68-1
3-[4-(3-(4-chloro)phenyl-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl]-2-propenoic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; for 24h;
DOI:10.1021/jm034167p DOI:10.1021/jm049002a

Reference yield:

: 2769-90-6
ethyl (2E)-3-(1-methyl-1H-pyrrol-2-yl)prop-2-enoate

: 615252-68-1
3-[4-(3-(4-chloro)phenyl-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl]-2-propenoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl chloride / 1,2-dichloro-ethane / 0.25 h / 20 °C

1.2: 74 percent / 1,2-dichloro-ethane

2.1: 75 percent / aq. KOH / ethanol / 24 h / 20 °C

With potassium hydroxide; oxalyl dichloride; In ethanol; 1,2-dichloro-ethane; 1.2: Vilsmeier-Haack formylation;
DOI:10.1021/jm049002a

Reference yield:

: 1192-58-1
N-methylpyrrole aldehyde

: 615252-68-1
3-[4-(3-(4-chloro)phenyl-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl]-2-propenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃ / ethanol / 80 °C

2.1: oxalyl chloride / 1,2-dichloro-ethane / 0.25 h / 20 °C

2.2: 74 percent / 1,2-dichloro-ethane / 1 h / 20 °C

3.1: 75 percent / aq. KOH / ethanol / 24 h / 20 °C

With potassium hydroxide; oxalyl dichloride; potassium carbonate; In ethanol; 1,2-dichloro-ethane; 2.1: Vilsmeier-Haack reaction;
DOI:10.1021/jm034167p