ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodonaphthalen-1-yl)methyl)piperidine-4-carboxylate

Base Information

Chemical Name:ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodonaphthalen-1-yl)methyl)piperidine-4-carboxylate
CAS No.:1621065-15-3
Molecular Formula:C₂₉H₄₀INO₃
Molecular Weight:577.546
Hs Code.:

Synonyms:ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodonaphthalen-1-yl)methyl)piperidine-4-carboxylate

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Chemical Property of ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodonaphthalen-1-yl)methyl)piperidine-4-carboxylate

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Technology Process of ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodonaphthalen-1-yl)methyl)piperidine-4-carboxylate

There total 5 articles about ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodonaphthalen-1-yl)methyl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1126-09-6
4-carbethoxypiperidine

: 1621064-75-2
2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodo-1-naphthaldehyde

: 1621065-15-3
ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodonaphthalen-1-yl)methyl)piperidine-4-carboxylate

Guidance literature:: 4-carbethoxypiperidine; 2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodo-1-naphthaldehyde; In ethyl acetate; at 40 ℃; for 4h;

With sodium tris(acetoxy)borohydride; In ethyl acetate; at 20 ℃;

Reference yield:

: 90800-21-8
4-iodonaphthalen-2-ol

: 1621065-15-3
ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodonaphthalen-1-yl)methyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tert-butyl alcohol; butanone / 4 h / 100 °C / Sealed tube

2.1: tin(IV) chloride / dichloromethane / 2 h / 0 - 20 °C

2.2: 2 h / 0 - 20 °C

2.3: 1 h / 20 °C

3.1: ethyl acetate / 4 h / 40 °C

3.2: 20 °C

With tin(IV) chloride; caesium carbonate; In dichloromethane; ethyl acetate; butanone; tert-butyl alcohol;

Reference yield:

: 937-05-3
cis-4-tert-butyl-1-cyclohexanol

: 1621065-15-3
ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodonaphthalen-1-yl)methyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 6 h / Reflux

2.1: tin(IV) chloride / dichloromethane / 2 h / 0 - 20 °C

2.2: 2 h / 0 - 20 °C

2.3: 1 h / 20 °C

3.1: ethyl acetate / 4 h / 40 °C

3.2: 20 °C

With di-isopropyl azodicarboxylate; tin(IV) chloride; triphenylphosphine; In dichloromethane; ethyl acetate; toluene;