(2R,3S)-3-[2-((1S,2R)-1-Benzyl-2-hydroxy-3-phenyl-propylamino)-ethylamino]-1,4-diphenyl-butan-2-ol

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Chemical Name:(2R,3S)-3-[2-((1S,2R)-1-Benzyl-2-hydroxy-3-phenyl-propylamino)-ethylamino]-1,4-diphenyl-butan-2-ol
CAS No.:214625-91-9
Molecular Formula:C₃₄H₄₀N₂O₂
Molecular Weight:508.704
Hs Code.:

Synonyms:(2R,3S)-3-[2-((1S,2R)-1-Benzyl-2-hydroxy-3-phenyl-propylamino)-ethylamino]-1,4-diphenyl-butan-2-ol

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Chemical Property of (2R,3S)-3-[2-((1S,2R)-1-Benzyl-2-hydroxy-3-phenyl-propylamino)-ethylamino]-1,4-diphenyl-butan-2-ol

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Technology Process of (2R,3S)-3-[2-((1S,2R)-1-Benzyl-2-hydroxy-3-phenyl-propylamino)-ethylamino]-1,4-diphenyl-butan-2-ol

There total 6 articles about (2R,3S)-3-[2-((1S,2R)-1-Benzyl-2-hydroxy-3-phenyl-propylamino)-ethylamino]-1,4-diphenyl-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 214625-90-8
N,N'-bis-[1-benzyl-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propyl]-ethane-1,2-diamine

: 214625-91-9
(2R,3S)-3-[2-((1S,2R)-1-Benzyl-2-hydroxy-3-phenyl-propylamino)-ethylamino]-1,4-diphenyl-butan-2-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 36h;
DOI:10.1016/S0040-4020(98)00675-9

Reference yield:

: 214625-85-1
(2R,3R)-2,3-dibenzyloxirane

: 214625-91-9
(2R,3S)-3-[2-((1S,2R)-1-Benzyl-2-hydroxy-3-phenyl-propylamino)-ethylamino]-1,4-diphenyl-butan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / ammonium chloride; sodium azide / 2-methoxy-ethanol; H₂O / 17 h / 95 °C

2: 94 percent / imidazole / dimethylformamide / 42 h

3: 94 percent / triphenylphosphine / tetrahydrofuran / 18 h / Heating

4: 56 percent / pyridine / toluene

5: 69 percent / BH₃*THF / tetrahydrofuran / 48 h / Heating

6: 72 percent / tetrabutylammonium fluoride / tetrahydrofuran / 36 h / 20 °C

With pyridine; 1H-imidazole; sodium azide; borane-THF; ammonium chloride; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; 2-methoxy-ethanol; water; N,N-dimethyl-formamide; toluene; 1: Addition / 2: Etherification / 3: Elimination / 4: Acylation / 5: Reduction / 6: Hydrolysis;
DOI:10.1016/S0040-4020(98)00675-9

Reference yield:

: 214625-86-2
(2R,3S)-3-Azido-1,4-diphenyl-butan-2-ol

: 214625-91-9
(2R,3S)-3-[2-((1S,2R)-1-Benzyl-2-hydroxy-3-phenyl-propylamino)-ethylamino]-1,4-diphenyl-butan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / imidazole / dimethylformamide / 42 h

2: 94 percent / triphenylphosphine / tetrahydrofuran / 18 h / Heating

3: 56 percent / pyridine / toluene

4: 69 percent / BH₃*THF / tetrahydrofuran / 48 h / Heating

5: 72 percent / tetrabutylammonium fluoride / tetrahydrofuran / 36 h / 20 °C

With pyridine; 1H-imidazole; borane-THF; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1: Etherification / 2: Elimination / 3: Acylation / 4: Reduction / 5: Hydrolysis;
DOI:10.1016/S0040-4020(98)00675-9