2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-pyridin-3-ylpropionic acid ethyl ester

Base Information

Chemical Name:2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-pyridin-3-ylpropionic acid ethyl ester
CAS No.:856571-40-9
Molecular Formula:C₂₆H₂₄N₄O₄
Molecular Weight:456.501
Hs Code.:

Synonyms:2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-pyridin-3-ylpropionic acid ethyl ester

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Chemical Property of 2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-pyridin-3-ylpropionic acid ethyl ester

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Technology Process of 2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-pyridin-3-ylpropionic acid ethyl ester

There total 5 articles about 2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-pyridin-3-ylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 856571-21-6
2-(2-aminobenzoylamino)-3-pyridin-3-ylpropionic acid ethyl ester

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 856571-40-9
2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-pyridin-3-ylpropionic acid ethyl ester

Guidance literature:: Indole-2-carboxylic acid; With phosphorus pentachloride; acetyl chloride; at 20 ℃; for 3h;

2-(2-aminobenzoylamino)-3-pyridin-3-ylpropionic acid ethyl ester; With pyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2005.01.002

Reference yield:

: 105381-95-1,350228-35-2,93960-20-4,93960-21-5,343626-03-9
2-amino-3-pyridin-3-ylpropionic acid hydrochloride

: 856571-40-9
2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-pyridin-3-ylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / HCl / 2 h / Heating

2.1: 35 percent / Et₃N / ethyl acetate / 4 h / Heating

3.1: AcCl; PCl₅ / 3 h / 20 °C

3.2: 68 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; phosphorus pentachloride; triethylamine; acetyl chloride; In ethyl acetate;
DOI:10.1016/j.ejmech.2005.01.002

Reference yield:

: 118-48-9
isatoic anhydride

: 856571-40-9
2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-pyridin-3-ylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 35 percent / Et₃N / ethyl acetate / 4 h / Heating

2.1: AcCl; PCl₅ / 3 h / 20 °C

2.2: 68 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With phosphorus pentachloride; triethylamine; acetyl chloride; In ethyl acetate;
DOI:10.1016/j.ejmech.2005.01.002