(2S,3S)-2-{(2S,3R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid methoxymethyl ester

Base Information

Chemical Name:(2S,3S)-2-{(2S,3R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid methoxymethyl ester
CAS No.:802911-22-4
Molecular Formula:C₃₉H₄₆N₄O₉
Molecular Weight:714.816
Hs Code.:

(2S,3S)-2-{(2S,3R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid methoxymethyl ester

Synonyms:(2S,3S)-2-{(2S,3R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid methoxymethyl ester

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Chemical Property of (2S,3S)-2-{(2S,3R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid methoxymethyl ester

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Technology Process of (2S,3S)-2-{(2S,3R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid methoxymethyl ester

There total 9 articles about (2S,3S)-2-{(2S,3R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid methoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 802911-21-3
H-(βMe)Phe-Ile-OMOM

: 802911-20-2
N-Fmoc-3-(2R,1'R,2'R)-(trans-2'-nitrocyclopropyl)alanine

: 802911-19-9
Z-(β-Me)Phe-Ile-OMOM

: 802911-22-4
(2S,3S)-2-{(2S,3R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid methoxymethyl ester

Guidance literature:: Z-(β-Me)Phe-Ile-OMOM; With hydrogen; acetic acid; palladium on activated charcoal; In ethyl acetate; for 1h; ambient pressure;

N-Fmoc-3-(2R,1'R,2'R)-(trans-2'-nitrocyclopropyl)alanine; With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 4 ℃; for 0.166667h;

H-(βMe)Phe-Ile-OMOM; With thymidine 5'-phosphate; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1002/chem.200400249

Reference yield:

: 1026352-71-5
Ile-OMOM

: 802911-22-4
(2S,3S)-2-{(2S,3R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid methoxymethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: EDC; HOAt / CH₂Cl₂ / 0.17 h / 4 °C

1.2: 0.40 g / TMP / CH₂Cl₂ / 2 h / 20 °C

2.1: H₂; AcOH / Pd/C / ethyl acetate / 1 h / ambient pressure

3.1: H₂; AcOH / Pd/C / ethyl acetate / 1 h / ambient pressure

3.2: EDC; HOAt / CH₂Cl₂ / 0.17 h / 4 °C

3.3: 0.220 g / TMP / CH₂Cl₂ / 15 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1002/chem.200400249

Reference yield:

: 321524-72-5
N-Z-3-(2S,3R)-β-methylphenylalanine

: 802911-22-4
(2S,3S)-2-{(2S,3R)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid methoxymethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: EDC; HOAt / CH₂Cl₂ / 0.17 h / 4 °C

1.2: 0.40 g / TMP / CH₂Cl₂ / 2 h / 20 °C

2.1: H₂; AcOH / Pd/C / ethyl acetate / 1 h / ambient pressure

3.1: H₂; AcOH / Pd/C / ethyl acetate / 1 h / ambient pressure

3.2: EDC; HOAt / CH₂Cl₂ / 0.17 h / 4 °C

3.3: 0.220 g / TMP / CH₂Cl₂ / 15 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1002/chem.200400249