3-{ [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl]sulfonyl}-5-(trifluoromethyl)benzonitrile

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Chemical Name:3-{ [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl]sulfonyl}-5-(trifluoromethyl)benzonitrile
CAS No.:1429197-25-0
Molecular Formula:C₂₂H₂₂F₃N₅O₃S
Molecular Weight:493.51
Hs Code.:

Synonyms:3-{ [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl]sulfonyl}-5-(trifluoromethyl)benzonitrile

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Chemical Property of 3-{ [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl]sulfonyl}-5-(trifluoromethyl)benzonitrile

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Technology Process of 3-{ [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl]sulfonyl}-5-(trifluoromethyl)benzonitrile

There total 9 articles about 3-{ [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl]sulfonyl}-5-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1429197-25-0
3-{ [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl]sulfonyl}-5-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: benzene / 5 h / Reflux

2.1: triethylamine / 2-ethoxy-ethanol / 12 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

4.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C

4.2: 48 h / 20 °C

5.1: hydrogen; 20% palladium hydroxide-activated charcoal / tetrahydrofuran / 16 h / 50 °C / 1551.49 Torr

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C

7.1: N,N-dimethyl-formamide / 16 h / 130 °C

With lithium aluminium tetrahydride; 20% palladium hydroxide-activated charcoal; potassium tert-butylate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 2-ethoxy-ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;

Reference yield:

: 1429197-86-3
(7R,8aS)-2-{[3-bromo-5-(trifluoromethyl)phenyl]sulfonyl}-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

: copper(l) cyanide

: 1429197-25-0
3-{ [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl]sulfonyl}-5-(trifluoromethyl)benzonitrile

Guidance literature:: In N,N-dimethyl-formamide; at 130 ℃; for 16h;

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 1429197-25-0
3-{ [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl]sulfonyl}-5-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 4 h / 0 - 25 °C

2.1: benzene / 5 h / Reflux

3.1: triethylamine / 2-ethoxy-ethanol / 12 h / Reflux

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

5.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C

5.2: 48 h / 20 °C

6.1: hydrogen; 20% palladium hydroxide-activated charcoal / tetrahydrofuran / 16 h / 50 °C / 1551.49 Torr

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C

8.1: N,N-dimethyl-formamide / 16 h / 130 °C

With lithium aluminium tetrahydride; thionyl chloride; 20% palladium hydroxide-activated charcoal; potassium tert-butylate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 2-ethoxy-ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;