2-Benzylamino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile

Base Information

• Chemical Name: 2-Benzylamino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile
• CAS No.: 133308-72-2
• Molecular Formula: C₂₃H₂₇N₃O₂
• Molecular Weight: 377.486

Synonyms:2-Benzylamino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile

Chemical Property of 2-Benzylamino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile

Chemical Property:

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Technology Process of 2-Benzylamino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile

There total 1 articles about 2-Benzylamino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one (841-95-2) + potassium cyanide (151-50-8) + benzylamine (100-46-9) → 2-Benzylamino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile (133308-72-2)

Guidance literature:

With acetic acid; In water; at 40 ℃; for 20h; Irradiation; irrad. with ultrasound;

DOI:10.1016/S0040-4039(00)84777-2

Reference yield: 90.0%

(2R,11bS)-2-Benzylamino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile (133308-72-2,136334-27-5) + 3,4-dichlorophenylisocyanate (102-36-3) → (+/-)-2R*,11bS*-1'-Benzyl-3'-(3,4-dichlorophenyl)-4'-imino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidin>-2'-one (136334-47-9)

Guidance literature:

With triethylamine; In benzene; for 8h; Heating;

Reference yield: 85.0%

(2R,11bS)-2-Benzylamino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile (133308-72-2,136334-27-5) + m-chlorophenyl isocyanate (2909-38-8) → (+/-)-2R*,11bS*-1'-Benzyl-3'-(3-chlorophenyl)-4'-imino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidin>-2'-one (136334-46-8)

Guidance literature:

With triethylamine; In benzene; for 3h; Ambient temperature; sonication;

upstream raw materials:

9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one

potassium cyanide

benzylamine

Downstream raw materials:

(+/-)-2R^*,11bS^*-1'-Benzyl-3'-(4-chlorophenyl)-4'-imino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidin>-2'-one

(+/-)-2R^*,11bS^*-1'-Benzyl-3'-cyclohexyl-4'-imino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidin>-2'-one

(+/-)-2R^*,11bS^*-1'-Benzyl-3'-(3,4-dichlorophenyl)-4'-imino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidin>-2'-one

(+/-)-2R^*,11bS^*-1'-Benzyl-3'-(3-chlorophenyl)-4'-imino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidin>-2'-one

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