2-(3-fluoro-4-(methylsulfonamido)phenyl)-2-(3-fluorophenyl)acetic acid

Base Information

• Chemical Name: 2-(3-fluoro-4-(methylsulfonamido)phenyl)-2-(3-fluorophenyl)acetic acid
• CAS No.: 1072449-72-9
• Molecular Formula: C₁₅H₁₃F₂NO₄S
• Molecular Weight: 341.335

Synonyms:2-(3-fluoro-4-(methylsulfonamido)phenyl)-2-(3-fluorophenyl)acetic acid

Chemical Property of 2-(3-fluoro-4-(methylsulfonamido)phenyl)-2-(3-fluorophenyl)acetic acid

Chemical Property:

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Technology Process of 2-(3-fluoro-4-(methylsulfonamido)phenyl)-2-(3-fluorophenyl)acetic acid

There total 1 articles about 2-(3-fluoro-4-(methylsulfonamido)phenyl)-2-(3-fluorophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C17H17F2NO4S (1072449-71-8) → 2-(3-fluoro-4-(methylsulfonamido)phenyl)-2-(3-fluorophenyl)acetic acid (1072449-72-9)

Guidance literature:

C₁₇H₁₇F₂NO₄S; With lithium hydroxide; water; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

With hydrogenchloride; water; pH=3 - 4;

Reference yield:

2-(3-fluoro-4-(methylsulfonamido)phenyl)-2-(3-fluorophenyl)acetic acid (1072449-72-9) + (1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine (1254713-79-5) → C29H29ClF2N4O3S

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2017.08.020

upstream raw materials:

C₁₇H₁₇F₂NO₄S

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