3-(6-chloro-9H-purin-9-yl)-1-N-[(N-tert-butyloxycarbonyl-O-carbobenzyloxy)amino]propane

Base Information

Chemical Name:3-(6-chloro-9H-purin-9-yl)-1-N-[(N-tert-butyloxycarbonyl-O-carbobenzyloxy)amino]propane
CAS No.:210163-00-1
Molecular Formula:C₂₁H₂₄ClN₅O₅
Molecular Weight:461.905
Hs Code.:

Synonyms:3-(6-chloro-9H-purin-9-yl)-1-N-[(N-tert-butyloxycarbonyl-O-carbobenzyloxy)amino]propane

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Chemical Property of 3-(6-chloro-9H-purin-9-yl)-1-N-[(N-tert-butyloxycarbonyl-O-carbobenzyloxy)amino]propane

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Technology Process of 3-(6-chloro-9H-purin-9-yl)-1-N-[(N-tert-butyloxycarbonyl-O-carbobenzyloxy)amino]propane

There total 3 articles about 3-(6-chloro-9H-purin-9-yl)-1-N-[(N-tert-butyloxycarbonyl-O-carbobenzyloxy)amino]propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 944-81-0
3-(6-chloro-9H-purin-9-yl)propan-1-ol

: N-(tert-butoxycarbonyl)-O-(benzyloxycarbonyl)hydroxylamine

: 210163-00-1
3-(6-chloro-9H-purin-9-yl)-1-N-[(N-tert-butyloxycarbonyl-O-carbobenzyloxy)amino]propane

Guidance literature:: With dibenzyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 12h; Ambient temperature;
DOI:10.1016/S0040-4020(98)00359-7

Reference yield:

: 87-42-3
6-chloro-1H-purine

: 210163-00-1
3-(6-chloro-9H-purin-9-yl)-1-N-[(N-tert-butyloxycarbonyl-O-carbobenzyloxy)amino]propane

Guidance literature:: Multi-step reaction with 3 steps

1: PPh₃, DIAD / tetrahydrofuran / 16 h / 40 °C

2: KCN / methanol / 1.5 h / Ambient temperature

3: 92 percent / PPh₃, DBAD / tetrahydrofuran / 12 h / Ambient temperature

With potassium cyanide; di-isopropyl azodicarboxylate; dibenzyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4020(98)00359-7

Reference yield:

: Acetic acid 3-(6-chloro-purin-9-yl)-propyl ester

: 210163-00-1
3-(6-chloro-9H-purin-9-yl)-1-N-[(N-tert-butyloxycarbonyl-O-carbobenzyloxy)amino]propane

Guidance literature:: Multi-step reaction with 2 steps

1: KCN / methanol / 1.5 h / Ambient temperature

2: 92 percent / PPh₃, DBAD / tetrahydrofuran / 12 h / Ambient temperature

With potassium cyanide; dibenzyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4020(98)00359-7