(S)-2-(2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl)isoindoline-1,3-dione

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Chemical Name:(S)-2-(2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl)isoindoline-1,3-dione
CAS No.:1441058-72-5
Molecular Formula:C₃₁H₂₄F₆N₂O₄
Molecular Weight:602.533
Hs Code.:

Synonyms:(S)-2-(2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl)isoindoline-1,3-dione

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Chemical Property of (S)-2-(2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl)isoindoline-1,3-dione

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Technology Process of (S)-2-(2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl)isoindoline-1,3-dione

There total 10 articles about (S)-2-(2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1441058-70-3
(S)-2-(1,3-dioxoisoindolin-2-yl)-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)phenyl)butan-2-yl)acetamide

: 1441058-72-5
(S)-2-(2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl)isoindoline-1,3-dione

Guidance literature:: With water; sodium hydroxide; In methanol; at 69 - 130 ℃; for 0.916667h; Microwave irradiation;

Reference yield:

: 280776-44-5
4-(4,4,4-trifluorobutoxy)benzaldehyde

: 1441058-72-5
(S)-2-(2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: cesium fluoride / 1,2-dimethoxyethane / 16 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 3.5 h / 0 - 20 °C

3.1: dimethyl sulfoxide / 160 °C / Microwave irradiation

4.1: ammonium hydroxide / dimethyl sulfoxide; water / 48 h / Sealed tube

5.1: CHIRALCEL? OD-H / methanol

6.1: triphenylphosphine; trichloroacetonitrile / dichloromethane / 3 h / 20 °C

6.2: 20 °C

7.1: sodium hydroxide; water / methanol / 0.92 h / 69 - 130 °C / Microwave irradiation

With ammonium hydroxide; water; Dess-Martin periodane; trichloroacetonitrile; triphenylphosphine; cesium fluoride; sodium hydroxide; In methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1441058-72-5
(S)-2-(2-oxo-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

2.1: cesium fluoride / 1,2-dimethoxyethane / 16 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 3.5 h / 0 - 20 °C

4.1: dimethyl sulfoxide / 160 °C / Microwave irradiation

5.1: ammonium hydroxide / dimethyl sulfoxide; water / 48 h / Sealed tube

6.1: CHIRALCEL? OD-H / methanol

7.1: triphenylphosphine; trichloroacetonitrile / dichloromethane / 3 h / 20 °C

7.2: 20 °C

8.1: sodium hydroxide; water / methanol / 0.92 h / 69 - 130 °C / Microwave irradiation

With ammonium hydroxide; di-isopropyl azodicarboxylate; water; Dess-Martin periodane; trichloroacetonitrile; triphenylphosphine; cesium fluoride; sodium hydroxide; In methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;