Technology Process of 3-anilino-2-(4-ethyl-3,5-dimethoxybenzyl)acrylonitrile
There total 5 articles about 3-anilino-2-(4-ethyl-3,5-dimethoxybenzyl)acrylonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 92 percent / H2 / 10percent Pd/C / methanol
2: 78 percent / Br2, dioxane / diethyl ether / 0.5 h
3: K, NH3(liquid), Fe(NO3)3 / 3 h
4: 1.) HNO2, 2.) Cu2(CN)2, NaCN / 1.) 0 deg C, 2.) a) H2O, toluene, 0 deg C, 30 min, b) 60 deg C, 1 h
5: 70 percent / 90percent formic acid / Raney Ni / H2O / 6 h / Heating
6: t-BuOK / 2-methyl-propan-2-ol; dimethylsulfoxide / 1.5 h / 55 - 60 °C
With
1,4-dioxane; formic acid; Cu2(CN)2; sodium cyanide; potassium tert-butylate; ammonia; hydrogen; bromine; cis-nitrous acid; ferric nitrate;
palladium on activated charcoal; nickel;
In
methanol; diethyl ether; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jm00140a005
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 78 percent / Br2, dioxane / diethyl ether / 0.5 h
2: K, NH3(liquid), Fe(NO3)3 / 3 h
3: 1.) HNO2, 2.) Cu2(CN)2, NaCN / 1.) 0 deg C, 2.) a) H2O, toluene, 0 deg C, 30 min, b) 60 deg C, 1 h
4: 70 percent / 90percent formic acid / Raney Ni / H2O / 6 h / Heating
5: t-BuOK / 2-methyl-propan-2-ol; dimethylsulfoxide / 1.5 h / 55 - 60 °C
With
1,4-dioxane; formic acid; Cu2(CN)2; sodium cyanide; potassium tert-butylate; ammonia; bromine; cis-nitrous acid; ferric nitrate;
nickel;
In
diethyl ether; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jm00140a005
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) HNO2, 2.) Cu2(CN)2, NaCN / 1.) 0 deg C, 2.) a) H2O, toluene, 0 deg C, 30 min, b) 60 deg C, 1 h
2: 70 percent / 90percent formic acid / Raney Ni / H2O / 6 h / Heating
3: t-BuOK / 2-methyl-propan-2-ol; dimethylsulfoxide / 1.5 h / 55 - 60 °C
With
formic acid; Cu2(CN)2; sodium cyanide; potassium tert-butylate; cis-nitrous acid;
nickel;
In
water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jm00140a005
