5-bromo-3-(phenylthio)pyridin-2-amine

Base Information

• Chemical Name: 5-bromo-3-(phenylthio)pyridin-2-amine
• CAS No.: 953045-27-7
• Molecular Formula: C₁₁H₉BrN₂S
• Molecular Weight: 281.176
• Mol file: 953045-27-7.mol

Synonyms:5-bromo-3-(phenylthio)pyridin-2-amine

Chemical Property of 5-bromo-3-(phenylthio)pyridin-2-amine

Chemical Property:

Purity/Quality:

5-Bromo-3-(phenylthio)pyridin-2-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-3-(phenylthio)pyridin-2-amine

There total 5 articles about 5-bromo-3-(phenylthio)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.21%

2-nitro-3-(phenylthio)pyridine (953045-26-6) → 5-bromo-3-(phenylthio)pyridin-2-amine (953045-27-7)

Guidance literature:

2-nitro-3-(phenylthio)pyridine; With acetic acid; zinc; at 0 ℃; for 0.0833333h; Cooling with ice;

With bromine; In acetic acid; for 0.166667h;

Reference yield:

2-amino-3-(phenylthio)pyridine (64064-61-5) → 5-bromo-3-(phenylthio)pyridin-2-amine (953045-27-7)

Guidance literature:

With bromine; In dichloromethane; for 0.166667h;

Reference yield:

3-chloro-2-nitropyridine (54231-32-2) → 5-bromo-3-(phenylthio)pyridin-2-amine (953045-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: caesium carbonate / dimethyl sulfoxide / 1.5 h / 20 °C

2.1: acetic acid; zinc / 0.08 h / 0 °C / Cooling with ice

2.2: 0.17 h

With caesium carbonate; acetic acid; zinc; In dimethyl sulfoxide;

upstream raw materials:

2-nitro-3-(phenylthio)pyridine

2-amino-3-(phenylthio)pyridine

3-chloro-2-nitropyridine

thiophenol

Downstream raw materials:

1-benzoyl-3-(5-bromo-3-(phenylthio)pyridin-2-yl)thiourea

N-(5-bromo-3-(phenylthio)pyridin-2-yl)thiazolo[5,4-b]pyridin-2-amine hydrochloride

1-(5-bromo-3-(phenylthio)pyridin-2-yl)thiourea

Refernces

• 1、 -. "2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS". Page/Page column 46. . Retrieved 2008/12/04.