1-[2-(5-Phenyl-[1,2,4]oxadiazol-3-yl)-ethyl]-2-thiazol-4-yl-1H-benzoimidazole

Base Information

Chemical Name:1-[2-(5-Phenyl-[1,2,4]oxadiazol-3-yl)-ethyl]-2-thiazol-4-yl-1H-benzoimidazole
CAS No.:58575-68-1
Molecular Formula:C₂₀H₁₅N₅OS
Molecular Weight:373.438
Hs Code.:

Synonyms:1-[2-(5-Phenyl-[1,2,4]oxadiazol-3-yl)-ethyl]-2-thiazol-4-yl-1H-benzoimidazole

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Chemical Property of 1-[2-(5-Phenyl-[1,2,4]oxadiazol-3-yl)-ethyl]-2-thiazol-4-yl-1H-benzoimidazole

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Technology Process of 1-[2-(5-Phenyl-[1,2,4]oxadiazol-3-yl)-ethyl]-2-thiazol-4-yl-1H-benzoimidazole

There total 3 articles about 1-[2-(5-Phenyl-[1,2,4]oxadiazol-3-yl)-ethyl]-2-thiazol-4-yl-1H-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 104-88-1
4-chlorobenzaldehyde

: 58553-89-2
2-(4-thiazoyl)-1H-benzimidazole-1-propionamidoxime

: 58575-68-1
1-[2-(5-Phenyl-[1,2,4]oxadiazol-3-yl)-ethyl]-2-thiazol-4-yl-1H-benzoimidazole

Guidance literature:: With boron trifluoride diethyl etherate; In 1,4-dioxane; Heating;
DOI:10.1021/jm00147a019

Reference yield:

: 58553-88-1
3-(2-Thiazol-4-yl-benzoimidazol-1-yl)-propionitrile

: 58575-68-1
1-[2-(5-Phenyl-[1,2,4]oxadiazol-3-yl)-ethyl]-2-thiazol-4-yl-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride, K₂CO₃ / ethanol; H₂O / 24 h / Heating

2: 54 percent / BF₃*Et₂O / dioxane / Heating

With boron trifluoride diethyl etherate; hydroxylamine hydrochloride; potassium carbonate; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm00147a019

Reference yield:

: 148-79-8,98002-42-7
thiabendazole

: 58575-68-1
1-[2-(5-Phenyl-[1,2,4]oxadiazol-3-yl)-ethyl]-2-thiazol-4-yl-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: Triton B

2: hydroxylamine hydrochloride, K₂CO₃ / ethanol; H₂O / 24 h / Heating

3: 54 percent / BF₃*Et₂O / dioxane / Heating

With boron trifluoride diethyl etherate; hydroxylamine hydrochloride; N-benzyl-trimethylammonium hydroxide; potassium carbonate; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm00147a019