7-bromo-1-ethyl-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Chemical Name:7-bromo-1-ethyl-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide
CAS No.:313749-25-6
Molecular Formula:C₂₆H₃₂BrN₃O₂
Molecular Weight:498.463
Hs Code.:

Synonyms:7-bromo-1-ethyl-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Chemical Property of 7-bromo-1-ethyl-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Technology Process of 7-bromo-1-ethyl-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

There total 5 articles about 7-bromo-1-ethyl-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 719297-10-6
tert-butyl 4-{[(benzyloxy)carbonyl](ethyl)amino}butanoate

: 313749-25-6
7-bromo-1-ethyl-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂; aq. HCl / Pd/C / methanol / 3 h / 20 °C

2: 38 percent / K₂CO₃ / dimethylformamide / 73 h / 70 - 80 °C

3: 70 percent / potassium tert-butoxide / toluene; 2-methyl-propan-2-ol / 3 h / 90 °C

4: 94 percent / HCl / ethyl acetate / 20 °C

5: SOCl₂; DMF / tetrahydrofuran / 20 °C

6: Et₃N / tetrahydrofuran; dimethylformamide / 20 °C

With hydrogenchloride; thionyl chloride; potassium tert-butylate; hydrogen; potassium carbonate; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 3: Claisen-Schmidt cyclization;
DOI:10.1248/cpb.52.577

Reference yield:

: 76572-85-5
4-{[(benzyloxy)carbonyl](ethyl)amino}butanoic acid

: 313749-25-6
7-bromo-1-ethyl-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 42 percent / di-tert-butyl dicarbonate; 4-(N,N-dimethylamino)pyridine / 4 h / 20 °C

2: 100 percent / H₂; aq. HCl / Pd/C / methanol / 3 h / 20 °C

3: 38 percent / K₂CO₃ / dimethylformamide / 73 h / 70 - 80 °C

4: 70 percent / potassium tert-butoxide / toluene; 2-methyl-propan-2-ol / 3 h / 90 °C

5: 94 percent / HCl / ethyl acetate / 20 °C

6: SOCl₂; DMF / tetrahydrofuran / 20 °C

7: Et₃N / tetrahydrofuran; dimethylformamide / 20 °C

With hydrogenchloride; dmap; thionyl chloride; di-tert-butyl dicarbonate; potassium tert-butylate; hydrogen; potassium carbonate; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 4: Claisen-Schmidt cyclization;
DOI:10.1248/cpb.52.577