Pyrazole-3(or 5)-carboxylic acid, 4-propyl- (7CI)

Base Information

• Chemical Name: Pyrazole-3(or 5)-carboxylic acid, 4-propyl- (7CI)
• CAS No.: 92304-61-5
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.169
• Mol file: 92304-61-5.mol

Synonyms:Pyrazole-3(or5)-carboxylic acid, 4-propyl- (7CI)

Chemical Property of Pyrazole-3(or 5)-carboxylic acid, 4-propyl- (7CI)

Chemical Property:

• Boiling Point: 358.7±22.0 °C(Predicted)
• PKA: 15.75±0.50(Predicted)
• PSA: 65.98000
• Density: 1 +-.0.06 g/cm3(Predicted)
• LogP: 1.06040

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazole-3(or 5)-carboxylic acid, 4-propyl- (7CI)

There total 4 articles about Pyrazole-3(or 5)-carboxylic acid, 4-propyl- (7CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-propyl-1H-pyrazole-3-carboxylic acid ethyl ester (92939-26-9) → 4-propyl-1H-pyrazole-3-carboxylic acid (92304-61-5)

Guidance literature:

With hydrogenchloride; In water; for 3h; Reflux;

DOI:10.1002/jhet.1654

Reference yield:

ethyl hex-2-enoate (1552-67-6) → 4-propyl-1H-pyrazole-3-carboxylic acid (92304-61-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / water; diethyl ether / 0.17 h / 0 °C

1.2: 0 - 25 °C

2.1: bromine / diethyl ether / 0.17 h / 25 °C

3.1: hydrogenchloride / water / 3 h / Reflux

With hydrogenchloride; bromine; potassium hydroxide; In diethyl ether; water;

DOI:10.1002/jhet.1654

Reference yield:

C9H16N2O2 → 4-propyl-1H-pyrazole-3-carboxylic acid (92304-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / diethyl ether / 0.17 h / 25 °C

2: hydrogenchloride / water / 3 h / Reflux

With hydrogenchloride; bromine; In diethyl ether; water;

DOI:10.1002/jhet.1654

upstream raw materials:

4-propyl-1H-pyrazole-3-carboxylic acid ethyl ester

ethyl hex-2-enoate