1-chloro-4-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-3,3-dimethylbutan-2-one

Base Information

Chemical Name:1-chloro-4-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-3,3-dimethylbutan-2-one
CAS No.:1005478-45-4
Molecular Formula:C₃₁H₄₃ClN₂O₆S
Molecular Weight:607.211
Hs Code.:

Synonyms:1-chloro-4-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-3,3-dimethylbutan-2-one

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Chemical Property of 1-chloro-4-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-3,3-dimethylbutan-2-one

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Technology Process of 1-chloro-4-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-3,3-dimethylbutan-2-one

There total 18 articles about 1-chloro-4-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-3,3-dimethylbutan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959937-54-3
methyl 3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionate

: 1005478-45-4
1-chloro-4-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-3,3-dimethylbutan-2-one

Guidance literature:: Chloroiodomethane; With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; at -100 ℃; for 1h;

methyl 3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionate; In tetrahydrofuran; diethyl ether; hexane; at -100 - -78 ℃; for 1h;

With water; In tetrahydrofuran; diethyl ether; hexane;

Reference yield:

: 959937-57-6
3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

: 1005478-45-4
1-chloro-4-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-3,3-dimethylbutan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h

2.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 3 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 1 h / -100 °C

3.2: 1 h / -100 - -78 °C

With n-butyllithium; hydrogen; tetra-(n-butyl)ammonium iodide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; hexane; N,N-dimethyl-formamide;

Reference yield:

: 959937-54-3
methyl 3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionate

: 593-71-5
Chloroiodomethane

: 1005478-45-4
1-chloro-4-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-3,3-dimethylbutan-2-one

Guidance literature:: Chloroiodomethane; With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; at -100 ℃; for 1h;

methyl 3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionate; In tetrahydrofuran; diethyl ether; hexane; at -100 - -78 ℃;

With water; In tetrahydrofuran; diethyl ether; hexane;