4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol

Base Information

Chemical Name:4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol
CAS No.:922734-67-6
Molecular Formula:C₂₀H₃₈O₂Si
Molecular Weight:338.606
Hs Code.:

4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol

Synonyms:4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol

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Chemical Property of 4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol

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Technology Process of 4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol

There total 1 articles about 4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 80434-59-9,485843-44-5,796865-68-4
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde

: 4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol

: 922734-67-6
4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol

Guidance literature:: tert-Butyldimethyl(prop-2-ynyloxy)silane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.25h;

(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde; With cerium(III) chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12h;
DOI:10.1139/V06-095

Reference yield: 82.0%

: 922734-67-6
4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol

: 868744-80-3
(E)-(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-but-2-en-1-ol

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at -25 ℃; for 96h;
DOI:10.1139/V06-095

Reference yield:

: 922734-67-6
4-(tert-butyl-dimethyl-silanyloxy)-1-(2-isopropyl-5-methyl-cyclohexyl)-but-2-yn-1-ol

: (1S,2S,4R)-1-Isopropyl-4-methyl-2-vinylcyclohexane

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / Red-Al / tetrahydrofuran; toluene / 96 h / -25 °C

2: 94 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

3: 75 percent / CuCN / diethyl ether / -10 - 20 °C

4: (Cl)2(PCy₃)IMesRu=CHPh / CH₂Cl₂ / 3 h / 40 °C

With triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene](benzylidene)Ru(II) dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1139/V06-095