tert-butyl (4-chlorophenyl)sulfonyl(3-((3-(cyclopropylmethyl)-4-isobutoxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

Base Information

Chemical Name:tert-butyl (4-chlorophenyl)sulfonyl(3-((3-(cyclopropylmethyl)-4-isobutoxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate
CAS No.:1333144-78-7
Molecular Formula:C₃₃H₄₂ClNO₆S
Molecular Weight:616.219
Hs Code.:

Synonyms:tert-butyl (4-chlorophenyl)sulfonyl(3-((3-(cyclopropylmethyl)-4-isobutoxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (4-chlorophenyl)sulfonyl(3-((3-(cyclopropylmethyl)-4-isobutoxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl (4-chlorophenyl)sulfonyl(3-((3-(cyclopropylmethyl)-4-isobutoxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

There total 11 articles about tert-butyl (4-chlorophenyl)sulfonyl(3-((3-(cyclopropylmethyl)-4-isobutoxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1333144-71-0
2-(cyclopropylmethyl)-5-(3-(2-hydroxyethyl)benzyl)-3-isobutoxycyclopent-2-enone

: 133033-79-1
N-(tert-butoxycarbonyl)-4-chlorobenzenesulfonamide

: 1333144-78-7
tert-butyl (4-chlorophenyl)sulfonyl(3-((3-(cyclopropylmethyl)-4-isobutoxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm200980u

Reference yield: 78.0%

: 1333144-78-7
tert-butyl (4-chlorophenyl)sulfonyl(3-((3-(cyclopropylmethyl)-4-isobutoxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

Guidance literature:

Reference yield:

: 1333144-57-2
3-(2-((triisopropylsilyl)oxy)ethyl)benzaldehyde

: 1333144-78-7
tert-butyl (4-chlorophenyl)sulfonyl(3-((3-(cyclopropylmethyl)-4-isobutoxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / Reflux

2.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 2 h / 0 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / -78 °C

3.2: -78 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; iodine; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; hexane; water; toluene; acetonitrile; 5.1: Mitsunobu reaction;
DOI:10.1021/jm200980u