tert-butyl (1S,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate

Base Information

Chemical Name:tert-butyl (1S,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate
CAS No.:350503-44-5
Molecular Formula:C₃₀H₃₉NO₄Si
Molecular Weight:505.729
Hs Code.:

Synonyms:tert-butyl (1S,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate

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Chemical Property of tert-butyl (1S,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate

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Technology Process of tert-butyl (1S,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate

There total 10 articles about tert-butyl (1S,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 4-nitro-benzoic acid 2-tert-butoxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxy)-1-phenyl-propyl ester

: 350503-44-5
tert-butyl (1S,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -20 ℃; for 1.5h;
DOI:10.1016/S0960-894X(02)00888-0

Reference yield:

: 116467-53-9,1377320-83-6
(S)-4-((R)-Hydroxy-phenyl-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 350503-44-5
tert-butyl (1S,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: p-TsOH / methanol / 7.5 h / 25 °C

2: imidazole / dimethylformamide

With 1H-imidazole; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00179-2