[3-(2,4-dichlorophenyl)-5-methyl-1H-pyrazolo[4,3-b]-pyridin-7-yl]-(1-methoxymethylpropyl)amine

Base Information

Chemical Name:[3-(2,4-dichlorophenyl)-5-methyl-1H-pyrazolo[4,3-b]-pyridin-7-yl]-(1-methoxymethylpropyl)amine
CAS No.:866141-72-2
Molecular Formula:C₁₈H₂₀Cl₂N₄O
Molecular Weight:379.289
Hs Code.:

Synonyms:[3-(2,4-dichlorophenyl)-5-methyl-1H-pyrazolo[4,3-b]-pyridin-7-yl]-(1-methoxymethylpropyl)amine

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Chemical Property of [3-(2,4-dichlorophenyl)-5-methyl-1H-pyrazolo[4,3-b]-pyridin-7-yl]-(1-methoxymethylpropyl)amine

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Technology Process of [3-(2,4-dichlorophenyl)-5-methyl-1H-pyrazolo[4,3-b]-pyridin-7-yl]-(1-methoxymethylpropyl)amine

There total 8 articles about [3-(2,4-dichlorophenyl)-5-methyl-1H-pyrazolo[4,3-b]-pyridin-7-yl]-(1-methoxymethylpropyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 63448-63-5
2-amino-1-methoxybutane

: 268547-49-5
7-chloro-3-(2,4-dichlorophenyl)-5-methylpyrazolo[4,3-b]pyridine

: 866141-72-2
[3-(2,4-dichlorophenyl)-5-methyl-1H-pyrazolo[4,3-b]-pyridin-7-yl]-(1-methoxymethylpropyl)amine

Guidance literature:: With toluene-4-sulfonic acid; at 130 ℃;
DOI:10.1021/jm049085v

Reference yield:

: 65146-53-4
2-[2-(2,4-dichlorophenyl)-2-oxoethyl]isoindoline-1,3-dione

: 866141-72-2
[3-(2,4-dichlorophenyl)-5-methyl-1H-pyrazolo[4,3-b]-pyridin-7-yl]-(1-methoxymethylpropyl)amine

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / 9 h / 82 °C

2: hydrazine monohydrochloride / ethanol; H₂O / 7 h / Heating

3: 761 g / hydrazine monohydrate / 1 h / Heating

4: p-toluenosulfonic acid / toluene / 4.5 h / Heating

5: 1.28 kg / diphenyl ether / 2 h / Heating

6: 95 percent / phosphorus oxychloride; DMF / acetonitrile / 3 h / Heating

7: 53 percent / p-toluenesulphonic acid monohydrate / 130 °C

With hydrazine hydrochloride; toluene-4-sulfonic acid; hydrazine hydrate; N,N-dimethyl-formamide; trichlorophosphate; In diphenylether; ethanol; water; toluene; acetonitrile;
DOI:10.1021/jm049085v

Reference yield:

: 268547-51-9
4-amino-3-(2,4-dichlorophenyl)-1H-pyrazole

: 866141-72-2
[3-(2,4-dichlorophenyl)-5-methyl-1H-pyrazolo[4,3-b]-pyridin-7-yl]-(1-methoxymethylpropyl)amine

Guidance literature:: Multi-step reaction with 4 steps

1: p-toluenosulfonic acid / toluene / 4.5 h / Heating

2: 1.28 kg / diphenyl ether / 2 h / Heating

3: 95 percent / phosphorus oxychloride; DMF / acetonitrile / 3 h / Heating

4: 53 percent / p-toluenesulphonic acid monohydrate / 130 °C

With toluene-4-sulfonic acid; N,N-dimethyl-formamide; trichlorophosphate; In diphenylether; toluene; acetonitrile;
DOI:10.1021/jm049085v