ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-ethyl-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

Base Information

Chemical Name:ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-ethyl-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate
CAS No.:146624-68-2
Molecular Formula:C₃₃H₃₉N₃O₅
Molecular Weight:557.69
Hs Code.:

Synonyms:ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-ethyl-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-ethyl-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-ethyl-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

There total 14 articles about ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-ethyl-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 146624-67-1
ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-ethynyl-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

: 146624-68-2
ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-ethyl-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 0.333333h; under 760 Torr; Ambient temperature;
DOI:10.1021/jm00045a016

Reference yield:

: 18441-43-5
5-methylbenzofuran

: 146624-68-2
ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-ethyl-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) n-BuLi, TMEDA, 2.) triisopropyl borate, 3.) tetrakis(triphenylphosphine)palladium, Na₂CO₃

2: 100 percent / Br₂ / CCl₄ / 0.67 h / 0 - 5 °C

3: 92 percent / aq. NaOH / methanol / 3 h / Heating

4: 18 percent / diphenylphosphorazidate, Et₃N / dioxane / 20 h / Heating

5: 97 percent / NBS, benzoyl peroxide / CCl₄ / 1.5 h / Heating; Irradiation

6: 62 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

7: 32 percent / bis(triphenylphosphine)palladium dichloride, CuI, diethylamine / 29 h / 90 °C

8: 72 percent / aq. NaOH / methanol; tetrahydrofuran / 16 h / Ambient temperature

9: 88 percent / H₂ / 10percent Pd/C / ethanol / 0.33 h / 760 Torr / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Perbenzoic acid; Triisopropyl borate; N,N,N,N,-tetramethylethylenediamine; diphenyl phosphoryl azide; hydrogen; bromine; sodium carbonate; potassium carbonate; diethylamine; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016

Reference yield:

: 610-94-6
2-bromobenzoic acid methyl ester

: 146624-68-2
ethyl 4-cyclopropyl-1-<<2-<-2<<(1-1,1-dimethyletoxy)carbonyl>amino>phenyl>-3-ethyl-5-benzofuranyl>methyl>-2-ethyl-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) n-BuLi, TMEDA, 2.) triisopropyl borate, 3.) tetrakis(triphenylphosphine)palladium, Na₂CO₃

2: 100 percent / Br₂ / CCl₄ / 0.67 h / 0 - 5 °C

3: 92 percent / aq. NaOH / methanol / 3 h / Heating

4: 18 percent / diphenylphosphorazidate, Et₃N / dioxane / 20 h / Heating

5: 97 percent / NBS, benzoyl peroxide / CCl₄ / 1.5 h / Heating; Irradiation

6: 62 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

7: 32 percent / bis(triphenylphosphine)palladium dichloride, CuI, diethylamine / 29 h / 90 °C

8: 72 percent / aq. NaOH / methanol; tetrahydrofuran / 16 h / Ambient temperature

9: 88 percent / H₂ / 10percent Pd/C / ethanol / 0.33 h / 760 Torr / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Perbenzoic acid; Triisopropyl borate; N,N,N,N,-tetramethylethylenediamine; diphenyl phosphoryl azide; hydrogen; bromine; sodium carbonate; potassium carbonate; diethylamine; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016