1-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

Base Information

• Chemical Name: 1-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine
• CAS No.: 120086-48-8
• Molecular Formula: C₁₆H₁₇N
• Molecular Weight: 223.318
• Mol file: 120086-48-8.mol

Synonyms:1-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

Chemical Property of 1-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine

There total 10 articles about 1-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(±)-N-methyl-1-phenyl-1,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carboxamide → 1-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine (120086-48-8)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 140 ℃; for 4h; Microwave irradiation;

DOI:10.1002/anie.201802188

Reference yield:

1-phenyl-4,5-dihydro-3H-benzo[c]diazepine (56900-75-5) → 1-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine (120086-48-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 16h; Yield given; Heating;

DOI:10.1021/jm00126a016

Reference yield:

3-Phenylpropan-1-amine (2038-57-5) → 1-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine (120086-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 24 g / 10percent aq. NaOH / CH₂Cl₂ / 0.25 h

2: polyphosphoric acid / 4 h / 140 °C

3: NaBH₄ / ethanol / 16 h / Heating

With sodium hydroxide; sodium tetrahydroborate; PPA; In ethanol; dichloromethane;

DOI:10.1021/jm00126a016

upstream raw materials:

1-phenyl-4,5-dihydro-3H-benzo[c]diazepine

3-Phenylpropan-1-amine

N-(3-phenylpropyl)benzamide

benzoyl chloride